Linked Life Data

11823862

Source:http://linkedlifedata.com/resource/pubmed/id/11823862

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pubmed-article:11823862pubmed:abstractTextPhospholipase C gamma 1 (PLC-gamma 1) hydrolyses phosphatidylinositol-4,5-bisphosphate to the second messengers inositol-1,4,5-trisphosphate and diacylglycerol. PLC-gamma 1 also has mitogenic activity upon growth-factor-dependent tyrosine phosphorylation; however, this activity is not dependent on the phospholipase activity of PLC-gamma 1, but requires an SH3 domain. Here, we demonstrate that PLC-gamma 1 acts as a guanine nucleotide exchange factor (GEF) for PIKE (phosphatidylinositol-3-OH kinase (PI(3)K) enhancer). PIKE is a nuclear GTPase that activates nuclear PI(3)K activity, and mediates the physiological activation by nerve growth factor (NGF) of nuclear PI(3)K activity. This enzymatic activity accounts for the mitogenic properties of PLC-gamma 1.lld:pubmed
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pubmed-article:11823862pubmed:articleTitlePhospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE.lld:pubmed
pubmed-article:11823862pubmed:affiliationJohns Hopkins University School of Medicine, Department of Neuroscience, 725 N. Wolfe Street, Baltimore, Maryland 21205, USA.lld:pubmed
pubmed-article:11823862pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11823862pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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