11823757

Source:http://linkedlifedata.com/resource/pubmed/id/11823757

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0015011, umls-concept:C0031327, umls-concept:C0040879, umls-concept:C0066677, umls-concept:C1280500, umls-concept:C1708335
pubmed:issue	1
pubmed:dateCreated	2002-2-1
pubmed:abstractText	Modafinil has been reported to produce a concentration-related induction of CYP3A4/5 activity in vitro in primary cultures of human hepatocytes.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0372741
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Benzhydryl Compounds, http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers, http://linkedlifedata.com/resource/pubmed/chemical/CYP3A protein, human, http://linkedlifedata.com/resource/pubmed/chemical/CYP3A4 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Central Nervous System Stimulants, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System, http://linkedlifedata.com/resource/pubmed/chemical/Estradiol Congeners, http://linkedlifedata.com/resource/pubmed/chemical/Ethinyl Estradiol, http://linkedlifedata.com/resource/pubmed/chemical/Hypnotics and Sedatives, http://linkedlifedata.com/resource/pubmed/chemical/Mixed Function Oxygenases, http://linkedlifedata.com/resource/pubmed/chemical/Triazolam, http://linkedlifedata.com/resource/pubmed/chemical/modafinil
pubmed:status	MEDLINE
pubmed:month	Jan
pubmed:issn	0009-9236
pubmed:author	pubmed-author:AroraSanjayS, pubmed-author:HellriegelEdward TET, pubmed-author:NelsonMichaelM, pubmed-author:RobertsonPhilmorePJr
pubmed:issnType	Print
pubmed:volume	71
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	46-56
pubmed:dateRevised	2008-11-21
pubmed:meshHeading	pubmed-meshheading:11823757-Adult, pubmed-meshheading:11823757-Area Under Curve, pubmed-meshheading:11823757-Benzhydryl Compounds, pubmed-meshheading:11823757-Biological Markers, pubmed-meshheading:11823757-Central Nervous System Stimulants, pubmed-meshheading:11823757-Chromatography, High Pressure Liquid, pubmed-meshheading:11823757-Cytochrome P-450 CYP3A, pubmed-meshheading:11823757-Cytochrome P-450 Enzyme System, pubmed-meshheading:11823757-Drug Interactions, pubmed-meshheading:11823757-Estradiol Congeners, pubmed-meshheading:11823757-Ethinyl Estradiol, pubmed-meshheading:11823757-Female, pubmed-meshheading:11823757-Gas Chromatography-Mass Spectrometry, pubmed-meshheading:11823757-Half-Life, pubmed-meshheading:11823757-Humans, pubmed-meshheading:11823757-Hypnotics and Sedatives, pubmed-meshheading:11823757-Mass Spectrometry, pubmed-meshheading:11823757-Mixed Function Oxygenases, pubmed-meshheading:11823757-Single-Blind Method, pubmed-meshheading:11823757-Spectrophotometry, Ultraviolet, pubmed-meshheading:11823757-Triazolam
pubmed:year	2002
pubmed:articleTitle	Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers.
pubmed:affiliation	Department of Drug Disposition, Cephalon, Inc., West Chester, PA 19380, USA. proberts@cephalon.com
pubmed:publicationType	Journal Article, Clinical Trial, Randomized Controlled Trial