| pubmed-article:11823639 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11823639 | lifeskim:mentions | umls-concept:C0026649 | lld:lifeskim |
| pubmed-article:11823639 | lifeskim:mentions | umls-concept:C0027530 | lld:lifeskim |
| pubmed-article:11823639 | lifeskim:mentions | umls-concept:C0035868 | lld:lifeskim |
| pubmed-article:11823639 | lifeskim:mentions | umls-concept:C0085139 | lld:lifeskim |
| pubmed-article:11823639 | lifeskim:mentions | umls-concept:C0242485 | lld:lifeskim |
| pubmed-article:11823639 | pubmed:issue | 5556 | lld:pubmed |
| pubmed-article:11823639 | pubmed:dateCreated | 2002-2-1 | lld:pubmed |
| pubmed-article:11823639 | pubmed:abstractText | The motor enzyme kinesin makes hundreds of unidirectional 8-nanometer steps without detaching from or freely sliding along the microtubule on which it moves. We investigated the kinesin stepping mechanism by immobilizing a Drosophila kinesin derivative through the carboxyl-terminal end of the neck coiled-coil domain and measuring orientations of microtubules moved by single enzyme molecules at submicromolar adenosine triphosphate concentrations. The kinesin-mediated microtubule-surface linkage was sufficiently torsionally stiff (>/=2.0 +/- 0.9 x 10(-20) Newton meters per radian2) that stepping by the hypothesized symmetric hand-over-hand mechanism would produce 180 degree rotations of the microtubule relative to the immobilized kinesin neck. In fact, there were no rotations, a finding that is inconsistent with symmetric hand-over-hand movement. An alternative "inchworm" mechanism is consistent with our experimental results. | lld:pubmed |
| pubmed-article:11823639 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11823639 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11823639 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11823639 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11823639 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11823639 | pubmed:issn | 1095-9203 | lld:pubmed |
| pubmed-article:11823639 | pubmed:author | pubmed-author:RoeE JEJJr | lld:pubmed |
| pubmed-article:11823639 | pubmed:author | pubmed-author:ChungJohnsonJ | lld:pubmed |
| pubmed-article:11823639 | pubmed:author | pubmed-author:GellesJeffJ | lld:pubmed |
| pubmed-article:11823639 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:11823639 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11823639 | pubmed:volume | 295 | lld:pubmed |
| pubmed-article:11823639 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11823639 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11823639 | pubmed:pagination | 844-8 | lld:pubmed |
| pubmed-article:11823639 | pubmed:dateRevised | 2007-3-19 | lld:pubmed |
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| pubmed-article:11823639 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11823639 | pubmed:articleTitle | Distinguishing inchworm and hand-over-hand processive kinesin movement by neck rotation measurements. | lld:pubmed |
| pubmed-article:11823639 | pubmed:affiliation | Biophysics and Structural Biology Program, Biochemistry Department, Brandeis University, Waltham, MA 02454-9110, USA. | lld:pubmed |
| pubmed-article:11823639 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11823639 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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