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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5556
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pubmed:dateCreated |
2002-2-1
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pubmed:abstractText |
The pha-4 locus encodes a forkhead box A (FoxA/HNF3) transcription factor homolog that specifies organ identity for Caenorhabditis elegans pharyngeal cells. We used microarrays to identify pharyngeal genes and analyzed those genes to determine which were direct PHA-4 targets. Our data suggest that PHA-4 directly activates most or all pharyngeal genes. Furthermore, the relative affinity of PHA-4 for different TRTTKRY (R = A/G, K = T/G, Y = T/C) elements modulates the onset of gene expression, providing a mechanism to activate pharyngeal genes at different developmental stages. We suggest that direct transcriptional regulation of entire gene networks may be a common feature of organ identity genes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
295
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
821-5
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11823633-Animals,
pubmed-meshheading:11823633-Binding Sites,
pubmed-meshheading:11823633-Biological Evolution,
pubmed-meshheading:11823633-Caenorhabditis elegans,
pubmed-meshheading:11823633-Caenorhabditis elegans Proteins,
pubmed-meshheading:11823633-Consensus Sequence,
pubmed-meshheading:11823633-Embryo, Nonmammalian,
pubmed-meshheading:11823633-Embryonic Development,
pubmed-meshheading:11823633-Gene Expression Regulation, Developmental,
pubmed-meshheading:11823633-Genes, Helminth,
pubmed-meshheading:11823633-Genes, Reporter,
pubmed-meshheading:11823633-Introns,
pubmed-meshheading:11823633-Models, Genetic,
pubmed-meshheading:11823633-Mutation,
pubmed-meshheading:11823633-Myosins,
pubmed-meshheading:11823633-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:11823633-Pharynx,
pubmed-meshheading:11823633-Promoter Regions, Genetic,
pubmed-meshheading:11823633-Recombinant Fusion Proteins,
pubmed-meshheading:11823633-Trans-Activators
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pubmed:year |
2002
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pubmed:articleTitle |
Regulation of organogenesis by the Caenorhabditis elegans FoxA protein PHA-4.
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pubmed:affiliation |
Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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