Linked Life Data

11822882

Source:http://linkedlifedata.com/resource/pubmed/id/11822882

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-2-1
pubmed:abstractText
Doubly transgenic mice expressing both a mutated amyloid precursor protein and a mutated presenilin-1 protein accumulate A(beta) deposits as they age. The early A(beta) deposits were found to be primarily composed of fibrillar A(beta) and resembled compact amyloid plaques. As the mice aged, nonfibrillar A(beta) deposits increased in number and spread to regions not typically associated with amyloid plaques in Alzheimer's disease. The fibrillar, amyloid-containing deposits remained restricted to cortical and hippocampal structures and did not increase substantially beyond the 12-month time point. Even at early time points, the fibrillar deposits were associated with dystrophic neurites and activated astrocytes expressing elevated levels of glial fibrillary acidic protein. Microglia similarly demonstrated increased staining for complement receptor-3 in the vicinity of A(beta) deposits at early time points. However, when MHC-II staining was used to assess the degree of microglial activation, full activation was not detected until mice were 12 months or older. Overall, the regional pattern of A(beta) staining resembles that found in Alzheimer disease; however, a progression from diffuse A(beta) to more compact amyloid deposits is not observed in the mouse model. It is noted that the activation of microglia at 12 months is coincident with the apparent stabilization of fibrillar A(beta) deposits, raising the possibility that activated microglia might clear fibrillar A(beta) deposits at a rate similar to their rate of formation, thereby establishing a relatively steady-state level of amyloid-containing deposits.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0014-4886
pubmed:author
pubmed:copyrightInfo
©2002 Elsevier Science (USA).
pubmed:issnType
Print
pubmed:volume
173
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
183-95
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:11822882-Aging, pubmed-meshheading:11822882-Alzheimer Disease, pubmed-meshheading:11822882-Amyloid beta-Protein Precursor, pubmed-meshheading:11822882-Animals, pubmed-meshheading:11822882-Astrocytes, pubmed-meshheading:11822882-Brain, pubmed-meshheading:11822882-Brain Stem, pubmed-meshheading:11822882-Cell Count, pubmed-meshheading:11822882-Disease Models, Animal, pubmed-meshheading:11822882-Disease Progression, pubmed-meshheading:11822882-Glial Fibrillary Acidic Protein, pubmed-meshheading:11822882-Histocompatibility Antigens Class II, pubmed-meshheading:11822882-Immunohistochemistry, pubmed-meshheading:11822882-Membrane Proteins, pubmed-meshheading:11822882-Mice, pubmed-meshheading:11822882-Mice, Transgenic, pubmed-meshheading:11822882-Microglia, pubmed-meshheading:11822882-Neurites, pubmed-meshheading:11822882-Neurofibrillary Tangles, pubmed-meshheading:11822882-Neurons, pubmed-meshheading:11822882-Presenilin-1, pubmed-meshheading:11822882-Receptors, Complement
pubmed:year
2002
pubmed:articleTitle
Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse.
pubmed:affiliation
Alzheimer Research Laboratory, Department of Pharmacology, University of South Florida, Tampa, Florida 33612-4799, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't