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rdf:type |
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lifeskim:mentions |
umls-concept:C0001779,
umls-concept:C0007303,
umls-concept:C0009325,
umls-concept:C0029408,
umls-concept:C0035648,
umls-concept:C0086418,
umls-concept:C0162574,
umls-concept:C0427008,
umls-concept:C0441712,
umls-concept:C0442805,
umls-concept:C1882071
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pubmed:issue |
1
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pubmed:dateCreated |
2002-1-30
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pubmed:abstractText |
Age is an important risk factor for osteoarthritis (OA). During aging, nonenzymatic glycation results in the accumulation of advanced glycation end products (AGEs) in cartilage collagen. We studied the effect of AGE crosslinking on the stiffness of the collagen network in human articular cartilage.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0004-3591
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pubmed:author |
pubmed-author:BankRuud ARA,
pubmed-author:BaynesJohn WJW,
pubmed-author:BenZaken ChayaZC,
pubmed-author:BijlsmaJohannes W JJW,
pubmed-author:Brau-BenjaminOritO,
pubmed-author:DeGrootJeroenJ,
pubmed-author:LafeberFloris P J GFP,
pubmed-author:MaroudasAliceA,
pubmed-author:MizrahiJoeJ,
pubmed-author:SchalkwijkCasper GCG,
pubmed-author:TeKoppeleJohan MJM,
pubmed-author:ThorpeSuzanne RSR,
pubmed-author:VerzijlNicoleN
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
114-23
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11822407-Adult,
pubmed-meshheading:11822407-Aging,
pubmed-meshheading:11822407-Arginine,
pubmed-meshheading:11822407-Cartilage, Articular,
pubmed-meshheading:11822407-Collagen,
pubmed-meshheading:11822407-Cross-Linking Reagents,
pubmed-meshheading:11822407-Glycosylation End Products, Advanced,
pubmed-meshheading:11822407-Humans,
pubmed-meshheading:11822407-Lysine,
pubmed-meshheading:11822407-Osteoarthritis,
pubmed-meshheading:11822407-Pyruvaldehyde,
pubmed-meshheading:11822407-Regression Analysis,
pubmed-meshheading:11822407-Ribose,
pubmed-meshheading:11822407-Stress, Mechanical,
pubmed-meshheading:11822407-Tetroses
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pubmed:year |
2002
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pubmed:articleTitle |
Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis.
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pubmed:affiliation |
TNO Prevention and Health, Leiden, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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