Source:http://linkedlifedata.com/resource/pubmed/id/11820461
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2002-1-31
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pubmed:abstractText |
We have investigated the effects of thermal injury upon myelopoiesis. IL-3, GM-CSF, and IL-5 were used to stimulate myeloid colony formation. IL-3 induces early myeloid progenitors and a more developed myeloid progenitor, the granulocyte-macrophage colony-forming unit (GM-CFU), to multiply and develop into mature myeloid cells. GM-CSF induces GM-CFU to become mature myeloid cells, while IL-5 induces eosinophil progenitors to become mature eosinophils. Stem Cell Factor (SCF) + IL-6 and FLT3 ligand, which have no effect on colony formation by themselves, were used to enhance the effects of IL-3 and GM-CSF, respectively. We found that thermal injury increased the number of early myeloid progenitors and GM-CFU in the spleen with either IL-3 or GM-CSF as a stimulant. Thermal injury increased the number of early myeloid progenitors in the bone marrow when GM-CSF, but not IL-3, was used to stimulate colony growth. Also, thermal injury increased the numbers of eosinophil progenitors in rat spleen and bone marrow and increased splenic levels of IL-5 mRNA.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0360-3997
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
339-49
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11820461-Animals,
pubmed-meshheading:11820461-Bone Marrow,
pubmed-meshheading:11820461-Burns,
pubmed-meshheading:11820461-Cell Culture Techniques,
pubmed-meshheading:11820461-Colony-Forming Units Assay,
pubmed-meshheading:11820461-Cytokines,
pubmed-meshheading:11820461-Eosinophils,
pubmed-meshheading:11820461-Leukocyte Count,
pubmed-meshheading:11820461-Models, Animal,
pubmed-meshheading:11820461-Myeloid Progenitor Cells,
pubmed-meshheading:11820461-Myelopoiesis,
pubmed-meshheading:11820461-Rats,
pubmed-meshheading:11820461-Rats, Inbred Strains,
pubmed-meshheading:11820461-Spleen
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pubmed:year |
2001
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pubmed:articleTitle |
Thermal injury increases the number of eosinophil progenitors in rat spleen and bone marrow.
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pubmed:affiliation |
Shriners Hospital for Children, Cincinnati, OH, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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