To observe the inhibition of antisense oligonucleotides (asON) phosphorthioate to the tissue inhibitors metalloproteinase-1 (TIMP-1) gene and protein expression in the liver tissue of immunologically induced hepatic fibrosis rats. The possibility of reversing hepatic fibrosis through gene therapy was observed.
The Center of Infectious Disease Diagnosis and Treatment of PLA, Tangdu Hospital, Forth Military Medical University, Xi'an 710038, Shaanxi Province, China. nieqinghe@hotmail.com
