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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2002-4-4
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pubmed:abstractText |
To observe the inhibition of antisense oligonucleotides (asON) phosphorthioate to the tissue inhibitors metalloproteinase-1 (TIMP-1) gene and protein expression in the liver tissue of immunologically induced hepatic fibrosis rats. The possibility of reversing hepatic fibrosis through gene therapy was observed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1007-9327
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
363-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11819791-Animals,
pubmed-meshheading:11819791-Collagen Type I,
pubmed-meshheading:11819791-Collagen Type III,
pubmed-meshheading:11819791-Disease Models, Animal,
pubmed-meshheading:11819791-Female,
pubmed-meshheading:11819791-Gene Expression,
pubmed-meshheading:11819791-Gene Therapy,
pubmed-meshheading:11819791-Hepatocytes,
pubmed-meshheading:11819791-Immunohistochemistry,
pubmed-meshheading:11819791-Liver,
pubmed-meshheading:11819791-Liver Cirrhosis,
pubmed-meshheading:11819791-Microscopy, Electron,
pubmed-meshheading:11819791-Oligonucleotides, Antisense,
pubmed-meshheading:11819791-Procollagen,
pubmed-meshheading:11819791-RNA, Messenger,
pubmed-meshheading:11819791-Rats,
pubmed-meshheading:11819791-Rats, Wistar,
pubmed-meshheading:11819791-Tissue Inhibitor of Metalloproteinase-1
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pubmed:year |
2001
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pubmed:articleTitle |
Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis.
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pubmed:affiliation |
The Center of Infectious Disease Diagnosis and Treatment of PLA, Tangdu Hospital, Forth Military Medical University, Xi'an 710038, Shaanxi Province, China. nieqinghe@hotmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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