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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-1-30
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pubmed:abstractText |
To determine the effect of cyclosporin A (CSA) on aggrecanase- and matrix metalloproteinase (MMP)-mediated catabolism of proteoglycan (aggrecan) in articular cartilage explants stimulated with interleukin-1 (IL-1) in a culture system that mimics early pathologic processes associated with arthritic disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aggrecans,
http://linkedlifedata.com/resource/pubmed/chemical/Antirheumatic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Metalloendopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/NFATC Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/Tissue Inhibitor of...,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/aggrecanase
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
124-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11817583-Aggrecans,
pubmed-meshheading:11817583-Animals,
pubmed-meshheading:11817583-Antirheumatic Agents,
pubmed-meshheading:11817583-Cartilage, Articular,
pubmed-meshheading:11817583-Cattle,
pubmed-meshheading:11817583-Cells, Cultured,
pubmed-meshheading:11817583-Chondrocytes,
pubmed-meshheading:11817583-Cyclosporine,
pubmed-meshheading:11817583-DNA-Binding Proteins,
pubmed-meshheading:11817583-Dose-Response Relationship, Drug,
pubmed-meshheading:11817583-Endopeptidases,
pubmed-meshheading:11817583-Extracellular Matrix Proteins,
pubmed-meshheading:11817583-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:11817583-Interleukin-1,
pubmed-meshheading:11817583-Joint Diseases,
pubmed-meshheading:11817583-Lectins, C-Type,
pubmed-meshheading:11817583-Metalloendopeptidases,
pubmed-meshheading:11817583-NFATC Transcription Factors,
pubmed-meshheading:11817583-Nuclear Proteins,
pubmed-meshheading:11817583-Proteoglycans,
pubmed-meshheading:11817583-Tissue Inhibitor of Metalloproteinases,
pubmed-meshheading:11817583-Transcription Factors
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pubmed:year |
2002
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pubmed:articleTitle |
Cyclosporin A inhibition of aggrecanase-mediated proteoglycan catabolism in articular cartilage.
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pubmed:affiliation |
Connective Tissue Biology Laboratories, Cardiff School of Biosciences, Cardiff University, UK. LittleCB@Cardiff.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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