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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2002-1-29
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pubmed:abstractText |
Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen and an angiogenic inducer as well as a mediator of vascular permeability. The biological effects of VEGF are mediated by two tyrosine kinase receptors, Flt-1 (VEGFr-1) and KDR (VEGFR-2). VEGF is essential for developmental angiogenesis and is also required for female reproductive functions and endochondral bone formation. Substantial evidence also implicates VEGF in tumors and intraocular neovascular syndromes. Currently, several clinical trials are ongoing to test the hypothesis that inhibition of VEGF activity may be beneficial for these conditions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelial Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Vascular Endothelial...,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factors
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pubmed:status |
MEDLINE
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pubmed:issn |
0001-5792
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 S. Karger AG, Basel
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pubmed:issnType |
Print
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
148-56
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11815711-Animals,
pubmed-meshheading:11815711-Antibodies, Monoclonal,
pubmed-meshheading:11815711-Endothelial Growth Factors,
pubmed-meshheading:11815711-Female,
pubmed-meshheading:11815711-Humans,
pubmed-meshheading:11815711-Lymphokines,
pubmed-meshheading:11815711-Male,
pubmed-meshheading:11815711-Neovascularization, Pathologic,
pubmed-meshheading:11815711-Neovascularization, Physiologic,
pubmed-meshheading:11815711-Pregnancy,
pubmed-meshheading:11815711-Proto-Oncogene Proteins,
pubmed-meshheading:11815711-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:11815711-Receptors, Growth Factor,
pubmed-meshheading:11815711-Receptors, Vascular Endothelial Growth Factor,
pubmed-meshheading:11815711-Vascular Endothelial Growth Factor A,
pubmed-meshheading:11815711-Vascular Endothelial Growth Factor Receptor-1,
pubmed-meshheading:11815711-Vascular Endothelial Growth Factors
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pubmed:year |
2001
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pubmed:articleTitle |
The role of vascular endothelial growth factor in angiogenesis.
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pubmed:affiliation |
Department of Molecular Oncology, Genentech, Inc, South San Francisco, Calif 94080, USA. nf@gene.com
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pubmed:publicationType |
Journal Article,
Review
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