A first series of novel 1-aza-9-oxafluorenes has been prepared from 3-carbonyl substituted 1,4-dihydropyridines and p-benzoquinone as small-sized cytostatics. Biological evaluation has been carried out in various cancer cell-lines. First structure-activity relationships proved the 4-phenyl substituent to be more favorable than the 4-methyl substituent. Cytostatic properties are discussed.
Institute of Pharmaceutical Chemistry, Department of Pharmacy, Martin-Luther-University, Halle-Wittenberg, 4, Wolfgang-Langenbeck-Str., 06120 Halle, Germany.
