Source:http://linkedlifedata.com/resource/pubmed/id/11814809
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2002-1-29
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pubmed:abstractText |
A first series of novel 1-aza-9-oxafluorenes has been prepared from 3-carbonyl substituted 1,4-dihydropyridines and p-benzoquinone as small-sized cytostatics. Biological evaluation has been carried out in various cancer cell-lines. First structure-activity relationships proved the 4-phenyl substituent to be more favorable than the 4-methyl substituent. Cytostatic properties are discussed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-894X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
411-3
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11814809-Acetylation,
pubmed-meshheading:11814809-Antineoplastic Agents,
pubmed-meshheading:11814809-DNA, Neoplasm,
pubmed-meshheading:11814809-Drug Design,
pubmed-meshheading:11814809-Drug Screening Assays, Antitumor,
pubmed-meshheading:11814809-Fluorenes,
pubmed-meshheading:11814809-Humans,
pubmed-meshheading:11814809-Intercalating Agents,
pubmed-meshheading:11814809-Magnetic Resonance Spectroscopy,
pubmed-meshheading:11814809-Structure-Activity Relationship
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pubmed:year |
2002
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pubmed:articleTitle |
Synthesis and first biological evaluation of 1-aza-9-oxafluorenes as novel lead structures for the development of small-sized cytostatics.
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pubmed:affiliation |
Institute of Pharmaceutical Chemistry, Department of Pharmacy, Martin-Luther-University, Halle-Wittenberg, 4, Wolfgang-Langenbeck-Str., 06120 Halle, Germany.
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pubmed:publicationType |
Journal Article
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