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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2002-3-7
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pubmed:abstractText |
A novel structural analogue of kynurenine, 2-amino-4-[3'-hydroxyphenyl]-4-hydroxybutanoic acid 6, was synthesised as an inhibitor of kynureninase. The compound had a significant inhibitory effect on kynureninase from both rat and human, giving a K(i) of 100 nM. It was thus found that removal of the aryl amino group coupled with a reduction of the carbonyl group at position 7 of the alanine side chain greatly enhanced potency of the inhibitor.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-894X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
361-3
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11814797-Animals,
pubmed-meshheading:11814797-Drug Design,
pubmed-meshheading:11814797-Enzyme Inhibitors,
pubmed-meshheading:11814797-Humans,
pubmed-meshheading:11814797-Hydrolases,
pubmed-meshheading:11814797-Hydroxybutyrates,
pubmed-meshheading:11814797-Kinetics,
pubmed-meshheading:11814797-Liver,
pubmed-meshheading:11814797-Phenylbutyrates,
pubmed-meshheading:11814797-Rats,
pubmed-meshheading:11814797-Recombinant Proteins
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pubmed:year |
2002
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pubmed:articleTitle |
2-Amino-4-[3'-hydroxyphenyl]-4-hydroxybutanoic acid; a potent inhibitor of rat and recombinant human kynureninase.
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pubmed:affiliation |
School of Chemistry, University of St Andrews, St Andrews, Fife KY16 9ST, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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