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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2002-3-7
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pubmed:abstractText |
Gemini compounds of the type N(alpha),N(omega)-bis(N(alpha)-lauroyl arginine)alpha,omega-alkylenediamides or bis(Args) bind bacterial lipopolysaccharide and neutralize endotoxic activity in in vitro tumor necrosis factor-alpha and nitric oxide release assays. Sequestration of lipopolysaccharide results in protection in a murine model of endotoxemia. However, the bis(Args) compounds are cytotoxic by virtue of being highly membrane-active. The development of less surface-active analogues may yield potentially therapeutically useful compounds for the treatment of Gram-negative sepsis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
357-60
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11814796-Amides,
pubmed-meshheading:11814796-Animals,
pubmed-meshheading:11814796-Arginine,
pubmed-meshheading:11814796-Endotoxemia,
pubmed-meshheading:11814796-Endotoxins,
pubmed-meshheading:11814796-Hemolysis,
pubmed-meshheading:11814796-Indicators and Reagents,
pubmed-meshheading:11814796-Lipopolysaccharides,
pubmed-meshheading:11814796-Magnetic Resonance Spectroscopy,
pubmed-meshheading:11814796-Mass Spectrometry,
pubmed-meshheading:11814796-Mice,
pubmed-meshheading:11814796-Nitric Oxide,
pubmed-meshheading:11814796-Tumor Necrosis Factor-alpha
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pubmed:year |
2002
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pubmed:articleTitle |
Sequestration of bacterial lipopolysaccharide by bis(Args) gemini compounds.
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pubmed:affiliation |
Molecular Biosciences, 4043 Haworth Hall, University of Kansas, Lawrence, KS 66044, USA. sdavid@ku.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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