Source:http://linkedlifedata.com/resource/pubmed/id/11814790
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2002-3-7
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pubmed:abstractText |
Optically active phenylpropanoic acid derivatives [(S)-5, and (R)-5] were prepared, and their affinities for peroxisome proliferator-activated receptor (PPAR)alpha and PPAR gamma were evaluated. Binding assay and cell-based reporter assay indicated that the activity of these compounds is enantio-dependent, and resides exclusively on the (S)-isomer.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-894X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
333-5
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11814790-Crystallography, X-Ray,
pubmed-meshheading:11814790-Humans,
pubmed-meshheading:11814790-Molecular Conformation,
pubmed-meshheading:11814790-Phenylpropionates,
pubmed-meshheading:11814790-Protein Binding,
pubmed-meshheading:11814790-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:11814790-Stereoisomerism,
pubmed-meshheading:11814790-Structure-Activity Relationship,
pubmed-meshheading:11814790-Transcription Factors,
pubmed-meshheading:11814790-Transcriptional Activation
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pubmed:year |
2002
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pubmed:articleTitle |
Enantio-dependent binding and transactivation of optically active phenylpropanoic acid derivatives at human peroxisome proliferator-activated receptor alpha.
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pubmed:affiliation |
Discovery Research Laboratories, Kyorin Pharmaceutical Co., Ltd., 2399-1Mitarai, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. hiroyuki.miyachi@mb2.kyorin-pharm.co.jp
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pubmed:publicationType |
Journal Article
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