Source:http://linkedlifedata.com/resource/pubmed/id/11809491
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
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| pubmed:dateCreated |
2002-1-25
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| pubmed:abstractText |
We have previously reported that mesolimbic dopamine (DA) substrates are critically involved in the rewarding effects of opiates only during states of opiate-dependence and withdrawal. However, in previously drug-naive animals, opiate reward is mediated through a DA-independent neural system. In the present study, we report that bilateral microinjections of a DA receptor antagonist, alpha-flupenthixol (0.3-3 microg/0.5 microl) into the nucleus accumbens (NAc), blocks morphine reward (10 mg/kg, i.p.) in opiate-withdrawn animals, but not in opiate-naive animals, suggesting that accumbal dopamine receptors are required for opiate reward signaling in drug-deprived motivational states. Next, the role of dopamine was examined in the development of opiate dependence and somatic withdrawal, and expression of withdrawal aversions. Pretreatment with alpha-flupenthixol (0.8 mg/kg, i.p.) before morphine injections during the development of opiate dependence did not effect expression of withdrawal aversions or the expression of somatic withdrawal. We have previously reported that pretreatment with a dopamine receptor antagonist, alpha-flupenthixol, blocks the aversive effects of opiate withdrawal. We now report that pretreatment with a direct dopamine receptor agonist, apomorphine (1.0-5.0 mg/kg, i.p.) before conditioning in a state of withdrawal, also blocks the aversive effects of opiate withdrawal. We propose that the aversive motivational effects of opiate withdrawal may be mediated by a specific dopaminergic neuronal signal.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antipsychotic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Flupenthixol,
http://linkedlifedata.com/resource/pubmed/chemical/Lithium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Morphine,
http://linkedlifedata.com/resource/pubmed/chemical/Narcotics
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
0166-4328
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
1
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| pubmed:volume |
129
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
17-29
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11809491-Animals,
pubmed-meshheading:11809491-Antipsychotic Agents,
pubmed-meshheading:11809491-Avoidance Learning,
pubmed-meshheading:11809491-Conditioning, Operant,
pubmed-meshheading:11809491-Dopamine,
pubmed-meshheading:11809491-Flupenthixol,
pubmed-meshheading:11809491-Limbic System,
pubmed-meshheading:11809491-Lithium Chloride,
pubmed-meshheading:11809491-Male,
pubmed-meshheading:11809491-Microinjections,
pubmed-meshheading:11809491-Morphine,
pubmed-meshheading:11809491-Morphine Dependence,
pubmed-meshheading:11809491-Motivation,
pubmed-meshheading:11809491-Narcotics,
pubmed-meshheading:11809491-Nucleus Accumbens,
pubmed-meshheading:11809491-Rats,
pubmed-meshheading:11809491-Rats, Wistar,
pubmed-meshheading:11809491-Reward,
pubmed-meshheading:11809491-Substance Withdrawal Syndrome
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| pubmed:year |
2002
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| pubmed:articleTitle |
Motivational state determines the functional role of the mesolimbic dopamine system in the mediation of opiate reward processes.
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| pubmed:affiliation |
Department of Anatomy and Cell Biology, Neurobiology Research Group, University of Toronto, Medical Sciences Building, Toronto, Ont., Canada. stevelaviolette@hotmail.com
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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