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pubmed:abstractText |
The homologous genes Spin (spindlin) and Ssty were first identified as genes involved in gametogenesis and seem to occur in multiple copies in vertebrate genomes. The mouse spindlin (Spin) protein was reported to interact with the spindle apparatus during oogenesis and to be a target for cell-cycle-dependent phosphorylation. The transcript of the mouse Ssty gene is specific to sperm cells. In the chicken, spindlin was found to co-localize with SUMO-1 to nuclear dots during interphase in fibroblasts, but to co-localize with chromosomes during mitosis. Thus, Spin/Ssty genes might be important in the transition from sperm cells and oocytes to the early embryo, as well as in mitosis.
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