Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-1-23
pubmed:abstractText
Hematopoietic stem cells (HSCs) give rise to variety of hematopoietic cells via pluripotential progenitors and lineage-committed progenitors and are responsible for blood production throughout adult life. Amplification of HSCs or progenitors represents a potentially powerful approach to the treatment of various blood disorders and to applying gene therapy by bone marrow transplantation. Lnk is an adaptor protein regulating the production of B cells. Here we show that Lnk is also expressed in hematopoietic progenitors in bone marrow, and that in the absence of Lnk, the number and the hematopoietic ability of progenitors are significantly increased. Augmented growth signals through c-Kit partly contributed to the enhanced hematopoiesis by lnk-/- cells. Lnk was phosphorylated by and associated with c-Kit, and selectively inhibited c-Kit-mediated proliferation by attenuating phosphorylation of Gab2 and activation of mitogen-activated protein kinase cascade. These observations indicate that Lnk plays critical roles in the expansion and function of early hematopoietic progenitors, and provide useful clues for the amplification of hematopoietic progenitor cells.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-10068651, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-10072070, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-10374881, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-10393959, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-10514377, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-10582339, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-10644978, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-10777618, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-10799879, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-11062533, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-11067877, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-11114373, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-11287958, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-11348593, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-11449275, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-1281687, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-14104600, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-1711568, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-2456920, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-2457811, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-7534130, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-7621074, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-7686845, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-7687891, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-8524815, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-9169414, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-9233773, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-9269751, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-9391080, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-9636306, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-9856458, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-9885561, http://linkedlifedata.com/resource/pubmed/commentcorrection/11805142-9989826
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
195
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
151-60
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk.
pubmed:affiliation
Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. takakis@ims.u-tokyo.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't