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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
12
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pubmed:dateCreated |
2002-1-22
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pubmed:abstractText |
We report here the first case of large granular lymphocytes (LGL) expansion following non-myeloablative allo-BMT for chronic myeloid leukemia. We characterized the morphologic, phenotypic and functional features of the LGL subset amplified in vivo 14 months after allo-BMT. Our results indicate that LGL can mediate in vitro a cytolytic activity on tumor cells. In vivo, the timing of the LGL expansion was associated with a sustained complete molecular remission. These observations suggest that LGL are a subset with the properties of effector lymphocytes which may contribute to the graft-versus-tumor effect.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0268-3369
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pubmed:author |
pubmed-author:ArnouletCC,
pubmed-author:BlaiseDD,
pubmed-author:FauchetAA,
pubmed-author:GastautJ AJA,
pubmed-author:GauglerBB,
pubmed-author:IsnardonDD,
pubmed-author:MaraninchiDD,
pubmed-author:MohtyMM,
pubmed-author:MozziconacciM JMJ,
pubmed-author:OlivaHH,
pubmed-author:SaintyDD,
pubmed-author:VeyNN
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1157-60
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11803360-Bone Marrow Transplantation,
pubmed-meshheading:11803360-Cytotoxicity, Immunologic,
pubmed-meshheading:11803360-Graft vs Tumor Effect,
pubmed-meshheading:11803360-Humans,
pubmed-meshheading:11803360-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:11803360-Lymphocytosis,
pubmed-meshheading:11803360-Male,
pubmed-meshheading:11803360-Middle Aged,
pubmed-meshheading:11803360-T-Lymphocyte Subsets,
pubmed-meshheading:11803360-Transplantation, Homologous,
pubmed-meshheading:11803360-Transplantation Conditioning
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pubmed:year |
2001
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pubmed:articleTitle |
Large granular lymphocytes (LGL) following non-myeloablative allogeneic bone marrow transplantation: a case report.
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pubmed:affiliation |
Laboratoire d'Immunologie des Tumeurs, Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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