| pubmed-article:11803248 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11803248 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:11803248 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:11803248 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:11803248 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:11803248 | lifeskim:mentions | umls-concept:C0552639 | lld:lifeskim |
| pubmed-article:11803248 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11803248 | pubmed:dateCreated | 2002-1-22 | lld:pubmed |
| pubmed-article:11803248 | pubmed:abstractText | The effect of 17beta-estradiol on intracellular Ca(2+) concentrations ([Ca(2+)](i)) in Madin Darby canine kidney cells was investigated by using the fluorescent dye fura-2. 17Beta-estradiol (5-100 micromol/l) induced instantaneous increases in [Ca(2+)](i) in a concentration-dependent manner. Ca(2+) removal inhibited 45 +/- 15% of the Ca(2+) signal. In Ca(2+)-free medium, pretreatment with 50 micromol/l 17beta-estradiol abolished the [Ca(2+)](i) increases induced by 2 micromol/l carbonylcyanide m-chlorophenylhydrazone (CCCP; a mitochondrial uncoupler), 1 micromol/l thapsigargin (an endoplasmic reticulum Ca(2+) pump inhibitor) and 50 micromol/l brefeldin A (an antibiotic which disperses the Golgi complex), but pretreatment with brefeldin A, CCCP and thapsigargin only partly inhibited the 17beta-estradiol-induced [Ca(2+)](i) signal. Adding 3 mmol/l Ca(2+) increased [Ca(2+)](i) in cells pretreated with 5-100 micromol/l 17beta-estradiol in Ca(2+)-free medium. Pretreatment with 1 micromol/l U73122 to abolish the formation of inositol-1,4,5-trisphosphate inhibited 50% of the Ca(2+) release induced by 50 micromol/l 17beta-estradiol. 17Beta-estradiol (20 micromol/l) also increased [Ca(2+)](i) in human bladder cancer cells and prostate cancer cells. Collectively, this study shows that 17beta-estradiol evoked a significant internal Ca(2+) release and external Ca(2+) entry possibly in a nongenomic manner. | lld:pubmed |
| pubmed-article:11803248 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11803248 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11803248 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11803248 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11803248 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11803248 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11803248 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11803248 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11803248 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11803248 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11803248 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11803248 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11803248 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11803248 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11803248 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11803248 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11803248 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11803248 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11803248 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11803248 | pubmed:issn | 0031-7012 | lld:pubmed |
| pubmed-article:11803248 | pubmed:author | pubmed-author:TsengLi-LingL... | lld:pubmed |
| pubmed-article:11803248 | pubmed:author | pubmed-author:LeeKam-ChungK... | lld:pubmed |
| pubmed-article:11803248 | pubmed:author | pubmed-author:ChouKang-JuKJ | lld:pubmed |
| pubmed-article:11803248 | pubmed:author | pubmed-author:ChengJin-Shiu... | lld:pubmed |
| pubmed-article:11803248 | pubmed:author | pubmed-author:WangJue-LongJ... | lld:pubmed |
| pubmed-article:11803248 | pubmed:author | pubmed-author:JanChung-RenC... | lld:pubmed |
| pubmed-article:11803248 | pubmed:author | pubmed-author:ChenWei-Chuan... | lld:pubmed |
| pubmed-article:11803248 | pubmed:author | pubmed-author:TangKwong-Yui... | lld:pubmed |
| pubmed-article:11803248 | pubmed:author | pubmed-author:HuangJong-Khi... | lld:pubmed |
| pubmed-article:11803248 | pubmed:copyrightInfo | Copyright 2002 S. Karger AG, Basel | lld:pubmed |
| pubmed-article:11803248 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11803248 | pubmed:volume | 64 | lld:pubmed |
| pubmed-article:11803248 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11803248 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11803248 | pubmed:pagination | 84-90 | lld:pubmed |
| pubmed-article:11803248 | pubmed:dateRevised | 2005-11-3 | lld:pubmed |
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| pubmed-article:11803248 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11803248 | pubmed:articleTitle | Effect of 17beta-estradiol on intracellular Ca(2+) levels in renal tubular cells. | lld:pubmed |
| pubmed-article:11803248 | pubmed:affiliation | Division of Urology, Ping Tung Christian Hospital, Ping Tung, Taiwan. | lld:pubmed |
| pubmed-article:11803248 | pubmed:publicationType | Journal Article | lld:pubmed |
