|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2002-1-22
|
|
pubmed:abstractText |
The leukocyte migration induced by Phoneutria nigriventer spider venom (PNV) has been investigated in rats using the pleurisy model. Intrapleural injection of PNV (10-100 microg/cavity) caused a dose- and time-dependent leukocyte accumulation. The bradykinin B(2) receptor antagonist Hoe 140 (0.5 mg/kg) substantially inhibited PNV-induced cell accumulation, whereas the angiotensin-converting enzyme inhibitor captopril (2 mg/kg) potentiated by 80% this effect. The non-specific kallikrein inhibitor aprotinin and the plasma kallikrein inhibitor soybean trypsin inhibitor greatly reduced PNV-induced leukocyte migration, whereas the selective tissue kallikrein inhibitor P(ac)-F-S-R-EDDnp failed to affect PNV-induced responses. Treatment of rats with capsaicin (50 mg/kg) at the neonatal stage resulted in 67% inhibition of the PNV-induced cell migration. The neurokinin NK(1) receptor antagonist SR140333, but not the NK(2) receptor antagonist SR48968, reduced by 55% venom-induced cell accumulation. We conclude that bradykinin generation is involved in the PNV-induced pleural leukocyte migration in rats, where it can directly activate sensory nerves contributing to a neurogenic inflammatory mechanism.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin-Converting Enzyme...,
http://linkedlifedata.com/resource/pubmed/chemical/Aprotinin,
http://linkedlifedata.com/resource/pubmed/chemical/Benzamides,
http://linkedlifedata.com/resource/pubmed/chemical/Bradykinin,
http://linkedlifedata.com/resource/pubmed/chemical/Capsaicin,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Quinuclidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Bradykinin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurokinin-1,
http://linkedlifedata.com/resource/pubmed/chemical/SR 140333,
http://linkedlifedata.com/resource/pubmed/chemical/SR 48968,
http://linkedlifedata.com/resource/pubmed/chemical/Soybean Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Spider Venoms,
http://linkedlifedata.com/resource/pubmed/chemical/Trypsin Inhibitors
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0304-3940
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
318
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
158-62
|
|
pubmed:dateRevised |
2003-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:11803123-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:11803123-Animals,
pubmed-meshheading:11803123-Aprotinin,
pubmed-meshheading:11803123-Benzamides,
pubmed-meshheading:11803123-Bradykinin,
pubmed-meshheading:11803123-Capsaicin,
pubmed-meshheading:11803123-Chemotaxis, Leukocyte,
pubmed-meshheading:11803123-Dose-Response Relationship, Drug,
pubmed-meshheading:11803123-Leukocytes,
pubmed-meshheading:11803123-Male,
pubmed-meshheading:11803123-Neurogenic Inflammation,
pubmed-meshheading:11803123-Neurons, Afferent,
pubmed-meshheading:11803123-Piperidines,
pubmed-meshheading:11803123-Pleura,
pubmed-meshheading:11803123-Pleurisy,
pubmed-meshheading:11803123-Quinuclidines,
pubmed-meshheading:11803123-Rats,
pubmed-meshheading:11803123-Rats, Wistar,
pubmed-meshheading:11803123-Receptors, Bradykinin,
pubmed-meshheading:11803123-Receptors, Neurokinin-1,
pubmed-meshheading:11803123-Soybean Proteins,
pubmed-meshheading:11803123-Spider Venoms,
pubmed-meshheading:11803123-Trypsin Inhibitors
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Role of kinins and sensory neurons in the rat pleural leukocyte migration induced by Phoneutria nigriventer spider venom.
|
|
pubmed:affiliation |
Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, P.O. Box 6111, 13081-970, (SP), Campinas, Brazil.
|
|
pubmed:publicationType |
Journal Article
|
