| pubmed-article:11801676 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11801676 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:11801676 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11801676 | lifeskim:mentions | umls-concept:C0027627 | lld:lifeskim |
| pubmed-article:11801676 | lifeskim:mentions | umls-concept:C0598935 | lld:lifeskim |
| pubmed-article:11801676 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:11801676 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11801676 | pubmed:dateCreated | 2002-1-21 | lld:pubmed |
| pubmed-article:11801676 | pubmed:abstractText | We have previously implicated TNF-related apoptosis-inducing ligand (TRAIL) in innate immune surveillance against tumor development. In this study, we describe the use of TRAIL gene-targeted mice to demonstrate the key role of TRAIL in suppressing tumor initiation and metastasis. Liver and spleen mononuclear cells from TRAIL gene-targeted mice were devoid of TRAIL expression and TRAIL-mediated cytotoxicity. TRAIL gene-targeted mice were more susceptible to experimental and spontaneous tumor metastasis, and the immunotherapeutic value of alpha-galactosylceramide was diminished in TRAIL gene-targeted mice. TRAIL gene-targeted mice were also more sensitive to the chemical carcinogen methylcholanthrene. These results substantiated TRAIL as an important natural effector molecule used in the host defense against transformed cells. | lld:pubmed |
| pubmed-article:11801676 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11801676 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11801676 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11801676 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11801676 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11801676 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11801676 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:11801676 | pubmed:author | pubmed-author:TakedaKazuyos... | lld:pubmed |
| pubmed-article:11801676 | pubmed:author | pubmed-author:YagitaHideoH | lld:pubmed |
| pubmed-article:11801676 | pubmed:author | pubmed-author:SmythMark JMJ | lld:pubmed |
| pubmed-article:11801676 | pubmed:author | pubmed-author:CretneyErikaE | lld:pubmed |
| pubmed-article:11801676 | pubmed:author | pubmed-author:GlaccumMoiraM | lld:pubmed |
| pubmed-article:11801676 | pubmed:author | pubmed-author:PeschonJacque... | lld:pubmed |
| pubmed-article:11801676 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11801676 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11801676 | pubmed:volume | 168 | lld:pubmed |
| pubmed-article:11801676 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11801676 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11801676 | pubmed:pagination | 1356-61 | lld:pubmed |
| pubmed-article:11801676 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11801676 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11801676 | pubmed:articleTitle | Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice. | lld:pubmed |
| pubmed-article:11801676 | pubmed:affiliation | Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, A'Beckett Street, East Melbourne, 8006 Victoria, Australia. | lld:pubmed |
| pubmed-article:11801676 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11801676 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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