|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2002-1-21
|
|
pubmed:abstractText |
We have previously implicated TNF-related apoptosis-inducing ligand (TRAIL) in innate immune surveillance against tumor development. In this study, we describe the use of TRAIL gene-targeted mice to demonstrate the key role of TRAIL in suppressing tumor initiation and metastasis. Liver and spleen mononuclear cells from TRAIL gene-targeted mice were devoid of TRAIL expression and TRAIL-mediated cytotoxicity. TRAIL gene-targeted mice were more susceptible to experimental and spontaneous tumor metastasis, and the immunotherapeutic value of alpha-galactosylceramide was diminished in TRAIL gene-targeted mice. TRAIL gene-targeted mice were also more sensitive to the chemical carcinogen methylcholanthrene. These results substantiated TRAIL as an important natural effector molecule used in the host defense against transformed cells.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0022-1767
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
168
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1356-61
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:11801676-Adenocarcinoma,
pubmed-meshheading:11801676-Animals,
pubmed-meshheading:11801676-Apoptosis Regulatory Proteins,
pubmed-meshheading:11801676-Cell Division,
pubmed-meshheading:11801676-Cell Transformation, Neoplastic,
pubmed-meshheading:11801676-Cytotoxicity, Immunologic,
pubmed-meshheading:11801676-Disease Susceptibility,
pubmed-meshheading:11801676-Female,
pubmed-meshheading:11801676-Fibrosarcoma,
pubmed-meshheading:11801676-Gene Targeting,
pubmed-meshheading:11801676-Genetic Predisposition to Disease,
pubmed-meshheading:11801676-Kidney Neoplasms,
pubmed-meshheading:11801676-Killer Cells, Natural,
pubmed-meshheading:11801676-Ligands,
pubmed-meshheading:11801676-Liver Neoplasms,
pubmed-meshheading:11801676-Mammary Neoplasms, Experimental,
pubmed-meshheading:11801676-Membrane Glycoproteins,
pubmed-meshheading:11801676-Methylcholanthrene,
pubmed-meshheading:11801676-Mice,
pubmed-meshheading:11801676-Mice, Inbred BALB C,
pubmed-meshheading:11801676-Mice, Inbred C57BL,
pubmed-meshheading:11801676-Mice, Knockout,
pubmed-meshheading:11801676-Neoplasm Metastasis,
pubmed-meshheading:11801676-Neoplasm Transplantation,
pubmed-meshheading:11801676-TNF-Related Apoptosis-Inducing Ligand,
pubmed-meshheading:11801676-Tumor Cells, Cultured,
pubmed-meshheading:11801676-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice.
|
|
pubmed:affiliation |
Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, A'Beckett Street, East Melbourne, 8006 Victoria, Australia.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
