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rdf:type |
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lifeskim:mentions |
umls-concept:C0003596,
umls-concept:C0017651,
umls-concept:C0030705,
umls-concept:C0152349,
umls-concept:C0332120,
umls-concept:C0439852,
umls-concept:C0522503,
umls-concept:C0871261,
umls-concept:C1704259,
umls-concept:C1704632,
umls-concept:C1705987,
umls-concept:C1706817,
umls-concept:C2911692
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|
pubmed:issue |
1
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pubmed:dateCreated |
2002-1-21
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pubmed:abstractText |
Previous studies suggested that the hypo-activity of the external pallidus (GPe) might drive the hyper-activity of subthalamic neurons, which underlies the cardinal symptoms of Parkinson's disease. We have challenged this view, based on the so-called 'indirect pathway', by recording apomorphine effects from both structures of parkinsonian patients, at rest and during passive movements.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1388-2457
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
113
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
91-100
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pubmed:dateRevised |
2008-9-10
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pubmed:meshHeading |
pubmed-meshheading:11801429-Adult,
pubmed-meshheading:11801429-Aged,
pubmed-meshheading:11801429-Antiparkinson Agents,
pubmed-meshheading:11801429-Apomorphine,
pubmed-meshheading:11801429-Dopamine Agonists,
pubmed-meshheading:11801429-Electric Stimulation,
pubmed-meshheading:11801429-Electrophysiology,
pubmed-meshheading:11801429-Evoked Potentials,
pubmed-meshheading:11801429-Female,
pubmed-meshheading:11801429-Globus Pallidus,
pubmed-meshheading:11801429-Humans,
pubmed-meshheading:11801429-Male,
pubmed-meshheading:11801429-Middle Aged,
pubmed-meshheading:11801429-Movement,
pubmed-meshheading:11801429-Neural Pathways,
pubmed-meshheading:11801429-Neurons,
pubmed-meshheading:11801429-Neurosurgical Procedures,
pubmed-meshheading:11801429-Parkinson Disease,
pubmed-meshheading:11801429-Stereotaxic Techniques,
pubmed-meshheading:11801429-Subthalamus
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pubmed:year |
2002
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pubmed:articleTitle |
Subdyskinetic apomorphine responses in globus pallidus and subthalamus of parkinsonian patients: lack of clear evidence for the 'indirect pathway'.
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pubmed:affiliation |
Clinica Neurologica, Univ. di Tor Vergata, P. le Umanesimo 10, 00144 Rome, Italy.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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