Linked Life Data

1180125

Source:http://linkedlifedata.com/resource/pubmed/id/1180125

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1975-12-20
pubmed:abstractText
Endogenous production of carbon monoxide (VCO), serum bilirubin (SB) and reticulocyte (retic) count have been followed during the menstrual cycle in 12 women (4 of them smokers) without contraceptive drugs and in 10 women (5 of them smokers) on contraceptive drugs. During the progesterone phase (Pph), VCO in the non-smokers was 18.2 +/- 2.1 mumol/mmol total body heme (TBH) and day (mean +/- 1 S.E.M.), compared with 10.1 +/- 1.0 during the estrogen phase (Eph). In the smokers, VCO was 10.4 +/- 1.9 during Pph and 12.5 +/- 0.7 during Eph. SB for the non-smokers was 5.2+/- 1.0 mug/ml during Pph and 3.9 +/- 0.5 during Eph, compared with 3.2 +/- 0.8 and 3.9 +/- 1.2, respectively, for smokers. The retic count for the non-smokers was 64.1 +/- 4.7 times 10(3)/mul during Pph and 17.7 +/- 5.1 during Eph. In the smokers the corresponding counts were 93.6 +/- 15.9 and 60.8 +/- 7.6. These results confirm earlier reports that VCO is increased during Pph and indicate that the rise could be due to a change in red cell catabolism, since it is concomitant with a significant increase in retic counts, which has not been found in earlier works on VCO, but which is known from reticulocyte studies. Furthermore, the results may indicate that persistent smoking affects the metabolism of CO and/or heme, since the smokers did not react with any change in VCO during Pph. In subjects using contraceptive drugs, VCO was significantly higher (14.9 +/- 0.6 on combined estrogen-gestagen drugs and 14.5 +/- 1.1 on continuous gestagens, respectively) than during Eph in non-smokers (10.1 +/- 1.0 mumol/mmol TBH and day), which might be taken as the baseline group. This indicates that the increased VCO in subjects on contraceptive drugs may be related to the activity of gestagens, which were concluded in all contraceptive drugs tested.
pubmed:keyword
http://linkedlifedata.com/resource/pubmed/keyword/Biology, http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research, http://linkedlifedata.com/resource/pubmed/keyword/Contraception, http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Methods--side effects, http://linkedlifedata.com/resource/pubmed/keyword/Family Planning, http://linkedlifedata.com/resource/pubmed/keyword/Hematological Effects, http://linkedlifedata.com/resource/pubmed/keyword/Hemic System, http://linkedlifedata.com/resource/pubmed/keyword/Hemoglobin Level, http://linkedlifedata.com/resource/pubmed/keyword/Human Volunteers, http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives, Low-dose, http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives--side effects, http://linkedlifedata.com/resource/pubmed/keyword/Physiology, http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0001-6101
pubmed:author
pubmed:issnType
Print
pubmed:volume
198
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
155-60
pubmed:dateRevised
2004-11-17
pubmed:otherAbstract
PIP: The endogenous production of carbon monoxide (CM), serum bilirubin (SB), and reticulocyte (retic) count was studied in 12 women who were not taking oral contraceptives (OC), 4 of whom were smokers, and 10 women who were taking OCs, 5 of whom were smokers. Among non-smokers not using OCs, CM levels were significantly (p less than .001) higher during the progesterone phase (Pph) of the menstrual cycle than the estrogen phase (Eph). SB levels were not significantly different during Pph and Eph (p more than .05). Total body hemoglobin (TBH) did not change between phases. The rectic count was significantly higher during Pph than Eph (p less than .001). Among smokers not using OCs, CM did not significantly differ between the phases (p more than .05), but was significantly lower than those values for non-smokers during Pph (p less than .01), and probably significantly higher during (p less than .05). There were no differences in TBH between the phases and in comparison with non-smokers. The rectic count in smokers was significantly higher during Pph compared to Eph (p less than .01), and was also higher, in both phases, than values for non-smokers. CM and rectic counts, for both smokers and non-smokers, were significantly higher during Pph than Eph (p pess than .05, p less than .01, respectively). Among 4 women using a combined OC, 1 of whom smoked, there were no significant differences between CM levels during treatment and drug-free days. In 6 women using gestagens, 4 of whom were smokers and 2 of whom were using parenteral preparations, the non-smokers showed larger variations in CM from week to week than smokers. The increase in CM may be due to a change in red cell catabolism. Since CM was higher during Pph among subjects using OCs than among non-smokers during Eph, it is suggested that the increase in CM may be related to the activity of gestagens.
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Carbon monoxide production and reticulocyte count in normal women. Effect of contraceptive drugs and smoking.
pubmed:publicationType
Journal Article