|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5554
|
|
pubmed:dateCreated |
2002-1-18
|
|
pubmed:abstractText |
Blood vessels express estrogen receptors, but their role in cardiovascular physiology is not well understood. We show that vascular smooth muscle cells and blood vessels from estrogen receptor beta (ERbeta)-deficient mice exhibit multiple functional abnormalities. In wild-type mouse blood vessels, estrogen attenuates vasoconstriction by an ERbeta-mediated increase in inducible nitric oxide synthase expression. In contrast, estrogen augments vasoconstriction in blood vessels from ERbeta-deficient mice. Vascular smooth muscle cells isolated from ERbeta-deficient mice show multiple abnormalities of ion channel function. Furthermore, ERbeta-deficient mice develop sustained systolic and diastolic hypertension as they age. These data support an essential role for ERbeta in the regulation of vascular function and blood pressure.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Receptor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Receptor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Guanidines,
http://linkedlifedata.com/resource/pubmed/chemical/NOS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroarginine,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen,
http://linkedlifedata.com/resource/pubmed/chemical/fulvestrant,
http://linkedlifedata.com/resource/pubmed/chemical/pimagedine
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
1095-9203
|
|
pubmed:author |
pubmed-author:BaoLinL,
pubmed-author:BianZhaoZ,
pubmed-author:CoxDanielD,
pubmed-author:GustafssonJan-AkeJA,
pubmed-author:HodginJeffreyJ,
pubmed-author:KarasRichard HRH,
pubmed-author:KwoO SOS,
pubmed-author:LuPingP,
pubmed-author:MendelsohnMichael EME,
pubmed-author:ShaulPhilip WPW,
pubmed-author:SmithiesOliverO,
pubmed-author:ThorenPeterP
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
18
|
|
pubmed:volume |
295
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
505-8
|
|
pubmed:dateRevised |
2011-10-27
|
|
pubmed:meshHeading |
pubmed-meshheading:11799247-Adrenergic alpha-Agonists,
pubmed-meshheading:11799247-Animals,
pubmed-meshheading:11799247-Aorta,
pubmed-meshheading:11799247-Blood Pressure,
pubmed-meshheading:11799247-Cells, Cultured,
pubmed-meshheading:11799247-Estradiol,
pubmed-meshheading:11799247-Estrogen Antagonists,
pubmed-meshheading:11799247-Estrogen Receptor alpha,
pubmed-meshheading:11799247-Estrogen Receptor beta,
pubmed-meshheading:11799247-Guanidines,
pubmed-meshheading:11799247-Humans,
pubmed-meshheading:11799247-Hypertension,
pubmed-meshheading:11799247-Male,
pubmed-meshheading:11799247-Mice,
pubmed-meshheading:11799247-Mice, Knockout,
pubmed-meshheading:11799247-Muscle, Smooth, Vascular,
pubmed-meshheading:11799247-Nitric Oxide Synthase,
pubmed-meshheading:11799247-Nitric Oxide Synthase Type II,
pubmed-meshheading:11799247-Nitroarginine,
pubmed-meshheading:11799247-Patch-Clamp Techniques,
pubmed-meshheading:11799247-Phenylephrine,
pubmed-meshheading:11799247-Potassium Channels,
pubmed-meshheading:11799247-Receptors, Estrogen,
pubmed-meshheading:11799247-Vasoconstriction
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta.
|
|
pubmed:affiliation |
Molecular Cardiology Research Institute, New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, MA 02111, USA.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
