Linked Life Data

1179879

Source:http://linkedlifedata.com/resource/pubmed/id/1179879

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1975-12-23
pubmed:abstractText
An influenza A strain with temperature sensitive neuraminidase was used for investigation of the functional significance of neuraminidase in different stages of the replication cycle. Heat inactivation of the neuraminidase does not diminish infectivity. Therefore, neuraminidase is not necessary for adsorption, penetration, and uncoating. At temperatures which inhibited neuraminidase activity there was also a reduction of intracellular haemagglutinin production but based on observations with a recombinant strain this was considered to be the consequence of a separate ts defect. Using quantitative haemadsorption to determine virus-dependent alteration of the cellular membrane no evidence was found that neuraminidase is involved in this process. However, release of haemagglutinin was considerably reduced if neuraminidase activity was diminished by temperature elevation. This function of the enzyme in the latest stage of the replication cycle can be substituted by V. cholerae neuraminidase.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0300-9688
pubmed:author
pubmed:issnType
Print
pubmed:volume
232
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
178-88
pubmed:dateRevised
2009-6-5
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Functional significance of neuraminidase in the replication cycle of influenza viruses.
pubmed:publicationType
Journal Article