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pubmed:abstractText |
Cocaine dependence is a major health concern and there are no effective pharmacotherapies currently available. Although cocaine is an indirect DA agonist that binds to all three monoamine transporters, there is much evidence implicating a greater role for the dopamine (DAT) than norepinephrine (NET) and serotonin (SERT) transporters in the behavioral effects of cocaine. As such, several groups have developed compounds that exhibit high affinity and selectivity for the DAT.
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pubmed:affiliation |
Department of Pharmacology & Toxicology, Virginia Commonwealth University, 410 North 12th Street, Smith Building, P.O. Box 980613, Richmond, VA 23298-0613, USA. ccook@hsc.vcu.edu
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