Linked Life Data

11796221

Source:http://linkedlifedata.com/resource/pubmed/id/11796221

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-1-17
pubmed:abstractText
Diffusion of solutes and macromolecules in aqueous cellular compartments is required for numerous cellular processes including metabolism, second messenger signaling and protein-protein interactions. The view of the cell interior has evolved from that of a viscous gel to that of a watery but crowded compartment. Recent measurements of fluorescent probe diffusion using photobleaching, correlation microscopy and time-resolved anisotropy methods, have indicated unexpectedly high mobilities of small solutes and macromolecules. This review evaluates experimental evidence defining the rates and barriers for molecular diffusion in cells. Possible implications of regulated molecular diffusion as a rate-limiting step in cell metabolism, and with respect to the delivery of therapeutic agents, are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0968-0004
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
27-33
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Solute and macromolecule diffusion in cellular aqueous compartments.
pubmed:affiliation
1246 Health Sciences East Tower, Cardiovascular Research Institute, University of California-San Francisco, San Francisco, CA 94143-0521, USA. verkman@itsa.ucsf.edu
pubmed:publicationType
Journal Article, Review