Linked Life Data

11796179

Source:http://linkedlifedata.com/resource/pubmed/id/11796179

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-1-17
pubmed:abstractText
To investigate the relationships between serum concentrations of soluble adhesion molecules and hyperglycemia, insulin resistance, or other conventional risk factors in type 2 diabetes, we measured soluble intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), E-selectin (sE-selectin), insulin sensitivity, and conventional risk factors in 150 Japanese type 2 diabetic patients without apparent diabetic macroangiopathy. High serum concentrations of sVCAM-1 and sE-selectin were observed in patients with type 2 diabetes. Serum concentrations of soluble adhesion molecules were not significantly influenced by sex, hypertension, dyslipidemia, or microangiopathy. Spearman correlation showed that sVCAM-1 concentrations correlated significantly with fasting plasma glucose (FPG), fasting C-peptide, and insulin sensitivity [K index of the insulin tolerance test (K(ITT))] (rho=0.19,0.23, and -0.23, respectively). Soluble E-selectin concentrations correlated significantly with body mass index (BMI), FPG, fasting C-peptide, insulin sensitivity, and triglyceride (rho=0.33,0.42,0.26,-0.48, and 0.29, respectively). Multiple regression analysis showed that FPG, fasting C-peptide, and total cholesterol were independent factors that correlated with sVCAM-1 levels. BMI, FPG, and insulin sensitivity were independent factors that correlated with sE-selectin levels. Serum concentrations of sE-selectin significantly increased associated with clustering of conventional risk factors those obesity, hypertension, dyslipidemia, and current smoking (P<0.01). Thus, sVCAM-1 and sE-selectin levels are related to both hyperglycemia and insulin resistance. Soluble E-selectin levels may be related to obesity, hyperglycemia, and insulin resistance and may reflect the presence of a multiple risk factor clustering syndrome.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0168-8227
pubmed:author
pubmed:issnType
Print
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
131-8
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed-meshheading:11796179-Blood Glucose, pubmed-meshheading:11796179-Body Mass Index, pubmed-meshheading:11796179-C-Peptide, pubmed-meshheading:11796179-Cell Adhesion Molecules, pubmed-meshheading:11796179-Cholesterol, pubmed-meshheading:11796179-Diabetes Mellitus, Type 2, pubmed-meshheading:11796179-E-Selectin, pubmed-meshheading:11796179-Fasting, pubmed-meshheading:11796179-Female, pubmed-meshheading:11796179-Humans, pubmed-meshheading:11796179-Hyperglycemia, pubmed-meshheading:11796179-Insulin Resistance, pubmed-meshheading:11796179-Intercellular Adhesion Molecule-1, pubmed-meshheading:11796179-Male, pubmed-meshheading:11796179-Middle Aged, pubmed-meshheading:11796179-Risk Factors, pubmed-meshheading:11796179-Solubility, pubmed-meshheading:11796179-Triglycerides, pubmed-meshheading:11796179-Vascular Cell Adhesion Molecule-1
pubmed:year
2002
pubmed:articleTitle
Serum concentrations of soluble adhesion molecules are related to degree of hyperglycemia and insulin resistance in patients with type 2 diabetes mellitus.
pubmed:affiliation
Department of Diabetes and Metabolism, Sasebo Chuo Hospital, 15 Yamato-cho, Sasebo, Nagasaki 857-1195, Japan.
pubmed:publicationType
Journal Article