Linked Life Data

11796157

Source:http://linkedlifedata.com/resource/pubmed/id/11796157

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-1-17
pubmed:abstractText
Compelling evidence has indicated the involvement of extracellular ATP and adenosine in the mechanisms of synaptic plasticity and memory formation. In the present study, adult rats were trained in a step-down inhibitory avoidance task (IA) or submitted to isolated foot-shock (IF) (0.4 mA) before measuring ectonucleotidase activities in the synaptosomes of the anterior and posterior cingulate cortex (AC and PC, respectively) and the medial precentral area (Fr2). IA increased ATP and ADP hydrolysis immediately after training in the synaptosomes of PC and AC, respectively, (P<0.05). Foot-shock (independent of occurring during IA or IF) increased ATP hydrolysis in synaptosomes of AC and Fr2 immediately after application and decreased AIP hydrolysis in AC 90 min after application (P<0.05). Foot-shock (independent of occurring during IA or IF) increased ATP hydrolysis in PC immediately and 90 min after application, and in Fr2, but only immediately after application (P<0.05). These results suggest that the ectonucleotidase pathway responds to a mild foot-shock in AC, PC and Fr2 and may be involved in memory consolidation of step-down inhibitory avoidance in the cingulate cortex.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0166-4328
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
128
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
121-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Effects of inhibitory avoidance training and/or isolated foot-shock on ectonucleotidase activities in synaptosomes of the anterior and posterior cingulate cortex and the medial precentral area of adult rats.
pubmed:affiliation
Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-ANEXO, 90035-003, Porto Alegre RS, Brazil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't