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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-1-17
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pubmed:abstractText |
Overexpression of the anti-inflammatory cytokine interleukin-10 (IL-10) blocks atherosclerotic events in vivo, and IL-10 has been recently hailed as an "immunologic scalpel" for atherosclerosis. Alternatively, mice lacking IL-10 receiving atherogenic diets have increased occlusive lesions. It remains unclear whether such IL-10 modulation broadly applies to other forms of occlusive arterial remodeling. We hypothesized that lack of IL-10 would exacerbate, and exogenous or overexpression of IL-10 would abrogate low shear stress-induced neointimal hyperplasia (NIH).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-4804
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pubmed:author |
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pubmed:copyrightInfo |
(c)2001 Elsevier Science.
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pubmed:issnType |
Print
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
110-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11796006-Adenoviridae,
pubmed-meshheading:11796006-Animals,
pubmed-meshheading:11796006-Carotid Artery, Common,
pubmed-meshheading:11796006-Carotid Artery Diseases,
pubmed-meshheading:11796006-Female,
pubmed-meshheading:11796006-Gene Therapy,
pubmed-meshheading:11796006-Green Fluorescent Proteins,
pubmed-meshheading:11796006-Hyperplasia,
pubmed-meshheading:11796006-Indicators and Reagents,
pubmed-meshheading:11796006-Interleukin-10,
pubmed-meshheading:11796006-Ligation,
pubmed-meshheading:11796006-Luminescent Proteins,
pubmed-meshheading:11796006-Male,
pubmed-meshheading:11796006-Mice,
pubmed-meshheading:11796006-Mice, Inbred C57BL,
pubmed-meshheading:11796006-Mice, Knockout,
pubmed-meshheading:11796006-Stress, Mechanical,
pubmed-meshheading:11796006-Tunica Intima
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pubmed:year |
2002
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pubmed:articleTitle |
Interleukin-10 fails to modulate low shear stress-induced neointimal hyperplasia.
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pubmed:affiliation |
University of Florida College of Medicine, Gainesville, Florida 32610, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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