Linked Life Data

11793790

Source:http://linkedlifedata.com/resource/pubmed/id/11793790

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2002-1-16
pubmed:abstractText
We investigated the independent contributions of a candidate gene and an environmental factor, and the presence of gene x environment (G x E) interaction, in the etiology of a disease in the Genetic Analysis Workshop (GAW) 12 problem 2 simulated data using a two-stage approach utilizing both case-control and case-parent study designs. Using the case-control design, several SNPs within candidate gene 1 (CG1) and environmental factor 1 (dichotomized using the 75th percentile as a cut-off) (EXP) were independently associated with disease status, in models adjusted for age and sex. We found evidence of gene x environment (G x E) interaction between EXP and two single-nucleotide polymorphisms (SNPs) within CG1 using the case-control design. Using the case-parent study design in the same population, we detected association between SNPs within CG1 and disease, but no G x E interaction was detected.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0741-0395
pubmed:author
pubmed:issnType
Print
pubmed:volume
21 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S843-8
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Investigation of a candidate gene, environment, and G x E interaction using case-control and case-parent study designs.
pubmed:affiliation
Univ. of Colorado Health Sci. Center, Department of Preventive Medicine and Biometrics, 4200 East Ninth Ave., Box C245, Denver, CO 80262, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.