Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-1-23
pubmed:abstractText
Knowledge of the rate of point mutation is of fundamental importance, because mutations are a vital source of genetic novelty and a significant cause of human diseases. Currently, mutation rate is thought to vary many fold among genes within a genome and among lineages in mammals. We have conducted a computational analysis of 5,669 genes (17,208 sequences) from species representing major groups of placental mammals to characterize the extent of mutation rate differences among genes in a genome and among diverse mammalian lineages. We find that mutation rate is approximately constant per year and largely similar among genes. Similarity of mutation rates among lineages with vastly different generation lengths and physiological attributes points to a much greater contribution of replication-independent mutational processes to the overall mutation rate. Our results suggest that the average mammalian genome mutation rate is 2.2 x 10(-9) per base pair per year, which provides further opportunities for estimating species and population divergence times by using molecular clocks.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-10469563, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-10833199, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-10835487, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-10949301, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-10978293, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-11030650, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-11057667, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-11161749, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-11226267, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-11238422, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-11449272, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-11454778, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-11689942, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-1487823, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-2068073, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-2515290, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-2911369, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-3082006, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-3102974, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-3118047, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-3357886, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-3856856, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-5343515, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-7714909, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-8036164, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-8056314, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-8078402, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-8308912, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-8336541, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-8673286, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-9037043, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-9089078, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-9560386, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-9582070, http://linkedlifedata.com/resource/pubmed/commentcorrection/11792858-9689093
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
803-8
pubmed:dateRevised
2010-9-14
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Mutation rates in mammalian genomes.
pubmed:affiliation
Department of Biology, Arizona State University, Tempe, AZ 85287-1501, USA. skumar@asu.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't