| pubmed-article:11792663 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11792663 | lifeskim:mentions | umls-concept:C0024501 | lld:lifeskim |
| pubmed-article:11792663 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:11792663 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:11792663 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:11792663 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:11792663 | lifeskim:mentions | umls-concept:C0011777 | lld:lifeskim |
| pubmed-article:11792663 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:11792663 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
| pubmed-article:11792663 | lifeskim:mentions | umls-concept:C0721534 | lld:lifeskim |
| pubmed-article:11792663 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11792663 | pubmed:dateCreated | 2002-1-16 | lld:pubmed |
| pubmed-article:11792663 | pubmed:abstractText | Insulin-like growth factor-I (IGF-I) gene expression is regulated by nutritional and hormonal factors. High-dose glucocorticoids decrease food intake, and this confounds studies addressing glucocorticoid effects on IGF-I gene regulation. We investigated alterations in the hepatic IGF-I endocrine system induced by a catabolic dose of dexamethasone (Dex) in rats given adequate nutrition by continuous infusion of total parenteral nutrition (TPN) solution with or without IGF-I administration. The four TPN groups included control, +Dex, +IGF-I, and +IGF-I + Dex (n = 9-11/group). Dex induced a 12% loss of body weight in association with a 50% decrease in hepatic immunoreactive IGF-I, a 10% decrease in serum IGF-I, and no change in steady-state liver IGF-I mRNA or growth hormone (GH) receptor binding. Exogenous IGF-I increased serum IGF-I, attenuated Dex-induced catabolism, and did not reduce hepatic levels of IGF-I and IGF-I mRNA despite decreased serum GH. These data suggest that Dex-induced catabolism is associated with downregulation of the hepatic IGF-I endocrine system at the translational or posttranslational level when adequate nutrition is provided. | lld:pubmed |
| pubmed-article:11792663 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11792663 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11792663 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11792663 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11792663 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11792663 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11792663 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11792663 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11792663 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11792663 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11792663 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11792663 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11792663 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11792663 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11792663 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11792663 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11792663 | pubmed:issn | 0363-6119 | lld:pubmed |
| pubmed-article:11792663 | pubmed:author | pubmed-author:AdamsM PMP | lld:pubmed |
| pubmed-article:11792663 | pubmed:author | pubmed-author:MuraliSS | lld:pubmed |
| pubmed-article:11792663 | pubmed:author | pubmed-author:NeyD MDM | lld:pubmed |
| pubmed-article:11792663 | pubmed:author | pubmed-author:KritschK RKR | lld:pubmed |
| pubmed-article:11792663 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11792663 | pubmed:volume | 282 | lld:pubmed |
| pubmed-article:11792663 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11792663 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11792663 | pubmed:pagination | R528-36 | lld:pubmed |
| pubmed-article:11792663 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:11792663 | pubmed:meshHeading | pubmed-meshheading:11792663... | lld:pubmed |
| pubmed-article:11792663 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11792663 | pubmed:articleTitle | Dexamethasone decreases serum and liver IGF-I and maintains liver IGF-I mRNA in parenterally fed rats. | lld:pubmed |
| pubmed-article:11792663 | pubmed:affiliation | Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA. | lld:pubmed |
| pubmed-article:11792663 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11792663 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11792663 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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