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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-1-16
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pubmed:abstractText |
Insulin-like growth factor-I (IGF-I) gene expression is regulated by nutritional and hormonal factors. High-dose glucocorticoids decrease food intake, and this confounds studies addressing glucocorticoid effects on IGF-I gene regulation. We investigated alterations in the hepatic IGF-I endocrine system induced by a catabolic dose of dexamethasone (Dex) in rats given adequate nutrition by continuous infusion of total parenteral nutrition (TPN) solution with or without IGF-I administration. The four TPN groups included control, +Dex, +IGF-I, and +IGF-I + Dex (n = 9-11/group). Dex induced a 12% loss of body weight in association with a 50% decrease in hepatic immunoreactive IGF-I, a 10% decrease in serum IGF-I, and no change in steady-state liver IGF-I mRNA or growth hormone (GH) receptor binding. Exogenous IGF-I increased serum IGF-I, attenuated Dex-induced catabolism, and did not reduce hepatic levels of IGF-I and IGF-I mRNA despite decreased serum GH. These data suggest that Dex-induced catabolism is associated with downregulation of the hepatic IGF-I endocrine system at the translational or posttranslational level when adequate nutrition is provided.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0363-6119
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
282
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R528-36
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11792663-Animal Nutritional Physiological Phenomena,
pubmed-meshheading:11792663-Animals,
pubmed-meshheading:11792663-Antibodies,
pubmed-meshheading:11792663-Dexamethasone,
pubmed-meshheading:11792663-Endocrine System,
pubmed-meshheading:11792663-Gene Expression,
pubmed-meshheading:11792663-Glucocorticoids,
pubmed-meshheading:11792663-Growth Hormone,
pubmed-meshheading:11792663-Insulin-Like Growth Factor Binding Protein 3,
pubmed-meshheading:11792663-Insulin-Like Growth Factor I,
pubmed-meshheading:11792663-Liver,
pubmed-meshheading:11792663-Male,
pubmed-meshheading:11792663-Microsomes,
pubmed-meshheading:11792663-Organ Size,
pubmed-meshheading:11792663-Parenteral Nutrition, Total,
pubmed-meshheading:11792663-RNA, Messenger,
pubmed-meshheading:11792663-Rats,
pubmed-meshheading:11792663-Rats, Sprague-Dawley,
pubmed-meshheading:11792663-Receptors, Somatotropin
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pubmed:year |
2002
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pubmed:articleTitle |
Dexamethasone decreases serum and liver IGF-I and maintains liver IGF-I mRNA in parenterally fed rats.
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pubmed:affiliation |
Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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