|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2002-1-16
|
|
pubmed:abstractText |
Sarcopenia may be partly due to a loss in total fiber number by apoptosis. We have investigated age-related alterations in the mitochondria-mediated pathway leading to apoptosis in the gastrocnemius muscle from 6-mo-old and 24-mo-old male Fisher 344 rats. Apoptosis (mono- and oligonucleosome fragmentation) in the gastrocnemius muscle was increased by 50% in the old rats compared with the adult animals. Furthermore, there was a significant correlation between cytosolic cytochrome c and caspase-3 activity, although neither cytochrome c nor caspase-3 activity increased significantly with age. Furthermore, there was a significant correlation between caspase-3 activity and mono- and oligonucleosome fragmentation in the old rats only. Mitochondrial Bcl-2 and Bax were not altered with age. In vitro experiments demonstrated that activation of the caspase cascade in skeletal muscle might be limited by procaspase-9 activation. This is the first study to explore the role of apoptosis in sarcopenia and suggests that subtle changes in apoptosis are involved.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apaf1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptotic Protease-Activating...,
http://linkedlifedata.com/resource/pubmed/chemical/Bax protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Casp3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome c Group,
http://linkedlifedata.com/resource/pubmed/chemical/Endonucleases,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radicals,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleosomes,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-2-Associated X Protein
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0363-6119
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
282
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
R519-27
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:11792662-Aging,
pubmed-meshheading:11792662-Animals,
pubmed-meshheading:11792662-Apoptosis,
pubmed-meshheading:11792662-Apoptotic Protease-Activating Factor 1,
pubmed-meshheading:11792662-Caspase 3,
pubmed-meshheading:11792662-Caspases,
pubmed-meshheading:11792662-Cytochrome c Group,
pubmed-meshheading:11792662-Cytosol,
pubmed-meshheading:11792662-Endonucleases,
pubmed-meshheading:11792662-Free Radicals,
pubmed-meshheading:11792662-Male,
pubmed-meshheading:11792662-Mitochondria,
pubmed-meshheading:11792662-Muscle, Skeletal,
pubmed-meshheading:11792662-Nucleosomes,
pubmed-meshheading:11792662-Organ Size,
pubmed-meshheading:11792662-Oxidative Stress,
pubmed-meshheading:11792662-Proteins,
pubmed-meshheading:11792662-Proto-Oncogene Proteins,
pubmed-meshheading:11792662-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:11792662-Rats,
pubmed-meshheading:11792662-Rats, Inbred F344,
pubmed-meshheading:11792662-bcl-2-Associated X Protein
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Apoptosis in skeletal muscle with aging.
|
|
pubmed:affiliation |
University of Florida, Biochemistry of Aging Laboratory, College of Health and Human Performance, Center for Exercise Science, College of Medicine, Gainesville, Florida 32611, USA.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
