| pubmed-article:11792630 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11792630 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:11792630 | lifeskim:mentions | umls-concept:C0014467 | lld:lifeskim |
| pubmed-article:11792630 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:11792630 | lifeskim:mentions | umls-concept:C0442034 | lld:lifeskim |
| pubmed-article:11792630 | lifeskim:mentions | umls-concept:C0028959 | lld:lifeskim |
| pubmed-article:11792630 | lifeskim:mentions | umls-concept:C0271510 | lld:lifeskim |
| pubmed-article:11792630 | lifeskim:mentions | umls-concept:C0444669 | lld:lifeskim |
| pubmed-article:11792630 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:11792630 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11792630 | pubmed:dateCreated | 2002-1-16 | lld:pubmed |
| pubmed-article:11792630 | pubmed:abstractText | We have investigated the importance of cell-surface serine- and/or threonine-linked oligosaccharide adhesion molecules synthesized by the Golgi enzyme core 2 beta-1,6-N-acetylglucosaminyltransferase (C2GlcNAcT) in mediating eosinophil trafficking to the lung in studies utilizing C2GlcNAcT-I-deficient mice. The number of bronchoalveolar eosinophils, the number of lung eosinophils, and airway responsiveness to methacholine were not significantly different in C2GlcNAcT-I-deficient compared with wild-type mice sensitized and challenged by inhalation with ovalbumin. C2GlcNAcT-I-deficient mice do not demonstrate defects in neutrophil trafficking to the lung in response to lipopolysaccharide (LPS). In contrast, ragweed-sensitized C2GlcNAcT-I-deficient mice exhibit significantly reduced eosinophil trafficking to the peritoneal cavity in response to ragweed peritoneal challenge. C2GlcNAcT-I-deficient mice also have significantly reduced neutrophil trafficking to the peritoneal cavity in response to LPS challenge. Overall, these studies demonstrate an important role for serine/threonine-linked oligosaccharides synthesized by the Golgi enzyme C2GlcNAcT-I in eosinophil and neutrophil trafficking to the peritoneum but not for eosinophil or neutrophil trafficking to the lung. | lld:pubmed |
| pubmed-article:11792630 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11792630 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11792630 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11792630 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11792630 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11792630 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11792630 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11792630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11792630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11792630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11792630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11792630 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11792630 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11792630 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11792630 | pubmed:issn | 1040-0605 | lld:pubmed |
| pubmed-article:11792630 | pubmed:author | pubmed-author:SriramaraoPP | lld:pubmed |
| pubmed-article:11792630 | pubmed:author | pubmed-author:BroideDavid... | lld:pubmed |
| pubmed-article:11792630 | pubmed:author | pubmed-author:MillerMarinaM | lld:pubmed |
| pubmed-article:11792630 | pubmed:author | pubmed-author:CastanedaDieg... | lld:pubmed |
| pubmed-article:11792630 | pubmed:author | pubmed-author:NayarJyothiJ | lld:pubmed |
| pubmed-article:11792630 | pubmed:author | pubmed-author:ChoJae YounJY | lld:pubmed |
| pubmed-article:11792630 | pubmed:author | pubmed-author:RomanMarkM | lld:pubmed |
| pubmed-article:11792630 | pubmed:author | pubmed-author:ElliesLesley... | lld:pubmed |
| pubmed-article:11792630 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11792630 | pubmed:volume | 282 | lld:pubmed |
| pubmed-article:11792630 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11792630 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11792630 | pubmed:pagination | L259-66 | lld:pubmed |
| pubmed-article:11792630 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11792630 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11792630 | pubmed:articleTitle | Core 2 oligosaccharides mediate eosinophil and neutrophil peritoneal but not lung recruitment. | lld:pubmed |
| pubmed-article:11792630 | pubmed:affiliation | Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA. dbroide@ucsd.edu | lld:pubmed |
| pubmed-article:11792630 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11792630 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:14537 | entrezgene:pubmed | pubmed-article:11792630 | lld:entrezgene |
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