Source:http://linkedlifedata.com/resource/pubmed/id/11792630
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2002-1-16
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| pubmed:abstractText |
We have investigated the importance of cell-surface serine- and/or threonine-linked oligosaccharide adhesion molecules synthesized by the Golgi enzyme core 2 beta-1,6-N-acetylglucosaminyltransferase (C2GlcNAcT) in mediating eosinophil trafficking to the lung in studies utilizing C2GlcNAcT-I-deficient mice. The number of bronchoalveolar eosinophils, the number of lung eosinophils, and airway responsiveness to methacholine were not significantly different in C2GlcNAcT-I-deficient compared with wild-type mice sensitized and challenged by inhalation with ovalbumin. C2GlcNAcT-I-deficient mice do not demonstrate defects in neutrophil trafficking to the lung in response to lipopolysaccharide (LPS). In contrast, ragweed-sensitized C2GlcNAcT-I-deficient mice exhibit significantly reduced eosinophil trafficking to the peritoneal cavity in response to ragweed peritoneal challenge. C2GlcNAcT-I-deficient mice also have significantly reduced neutrophil trafficking to the peritoneal cavity in response to LPS challenge. Overall, these studies demonstrate an important role for serine/threonine-linked oligosaccharides synthesized by the Golgi enzyme C2GlcNAcT-I in eosinophil and neutrophil trafficking to the peritoneum but not for eosinophil or neutrophil trafficking to the lung.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bronchoconstrictor Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Methacholine Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/N-Acetylglucosaminyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Oligosaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/beta-1,3-galactosyl-O-glycosyl-glyco...
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
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| pubmed:issn |
1040-0605
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
282
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
L259-66
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11792630-Animals,
pubmed-meshheading:11792630-Asthma,
pubmed-meshheading:11792630-Bone Marrow,
pubmed-meshheading:11792630-Bronchial Hyperreactivity,
pubmed-meshheading:11792630-Bronchoconstrictor Agents,
pubmed-meshheading:11792630-Cell Movement,
pubmed-meshheading:11792630-Eosinophils,
pubmed-meshheading:11792630-Female,
pubmed-meshheading:11792630-Gene Expression,
pubmed-meshheading:11792630-Golgi Apparatus,
pubmed-meshheading:11792630-Lung,
pubmed-meshheading:11792630-Methacholine Chloride,
pubmed-meshheading:11792630-Mice,
pubmed-meshheading:11792630-Mice, Inbred C57BL,
pubmed-meshheading:11792630-Mice, Knockout,
pubmed-meshheading:11792630-N-Acetylglucosaminyltransferases,
pubmed-meshheading:11792630-Neutrophils,
pubmed-meshheading:11792630-Oligosaccharides,
pubmed-meshheading:11792630-Peritoneum,
pubmed-meshheading:11792630-Peritonitis,
pubmed-meshheading:11792630-Pneumonia,
pubmed-meshheading:11792630-Reverse Transcriptase Polymerase Chain Reaction
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| pubmed:year |
2002
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| pubmed:articleTitle |
Core 2 oligosaccharides mediate eosinophil and neutrophil peritoneal but not lung recruitment.
|
| pubmed:affiliation |
Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA. dbroide@ucsd.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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