Source:http://linkedlifedata.com/resource/pubmed/id/11792334
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2002-1-16
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| pubmed:abstractText |
We investigated the association between Helicobacter pylori (H. pylori) infection and coronary artery disease (CAD) in 2 study populations: (1) a cross-sectional study to determine risk of having CAD, and (2) a longitudinal study to determine risk of acute myocardial infarction (AMI) or death over a mean follow-up period of 3 years in patients with angiographically documented CAD. Blood samples were tested for serum immunoglobulin G antibodies to H. pylori and C-reactive protein (CRP) levels. Study 1: Of 391 patients (62% men, mean age 57 years), 41% had antibodies to H. pylori. CAD prevalence was 70% in H. pylori seropositive patients and 59% in seronegative patients (p = 0.03). Elevated CRP levels (>0.5 mg/dl) were significantly higher in patients with than without CAD (p = 0.02). By univariate analysis, CAD prevalence significantly increased stepwise depending on H. pylori seropositivity and elevated CRP levels (p = 0.008). Significance was lost after adjustment for traditional risk factors. Further analyses revealed that age was the critical confounder. Study 2: Of 929 patients (77% men, mean age 65 years), 56% had antibodies to H. pylori. By univariate analysis, the incidence of AMI or death was 22% in H. pylori seropositive patients and 18% in seronegative patients (p = 0.1). The adjusted hazard ratio of AMI or death for H. pylori seropositivity was 1.12 (95% confidence interval 0.81 to 1.54). Our data suggest that prior infection with H. pylori is not a major factor determining either risk of CAD, AMI, or death in patients with CAD.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0002-9149
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
15
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| pubmed:volume |
89
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
155-8
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11792334-Age Factors,
pubmed-meshheading:11792334-Aged,
pubmed-meshheading:11792334-C-Reactive Protein,
pubmed-meshheading:11792334-Chi-Square Distribution,
pubmed-meshheading:11792334-Coronary Angiography,
pubmed-meshheading:11792334-Coronary Disease,
pubmed-meshheading:11792334-Cross-Sectional Studies,
pubmed-meshheading:11792334-Female,
pubmed-meshheading:11792334-Helicobacter Infections,
pubmed-meshheading:11792334-Helicobacter pylori,
pubmed-meshheading:11792334-Humans,
pubmed-meshheading:11792334-Immunoglobulin G,
pubmed-meshheading:11792334-Logistic Models,
pubmed-meshheading:11792334-Longitudinal Studies,
pubmed-meshheading:11792334-Male,
pubmed-meshheading:11792334-Middle Aged,
pubmed-meshheading:11792334-Myocardial Infarction,
pubmed-meshheading:11792334-Prevalence,
pubmed-meshheading:11792334-Risk Factors
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| pubmed:year |
2002
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| pubmed:articleTitle |
Lack of association of Helicobacter pylori infection with coronary artery disease and frequency of acute myocardial infarction or death.
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| pubmed:affiliation |
Cardiovascular Research Institute of the MedStar Research Institute, Washington Hospital Center, Washington, DC 20010, USA.
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| pubmed:publicationType |
Journal Article
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