Source:http://linkedlifedata.com/resource/pubmed/id/11791958
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2002-1-15
|
| pubmed:abstractText |
The efficacy of artemisinin monotherapy was studied in 227 patients with uncomplicated falciparum malaria. They all received artemisinin at t = 0 hr, t = 8 hr, and thereafter once daily; treatment was extended at random until they had taken either 5 days of artemisinin followed by 2 days of placebo (A5), or 7 days (A7) of artemisinin. The adult artemisinin dose was 500 mg; children aged < 15 years received 10 mg/kg per dose. The median (range) parasite clearance time was 39 (8-112) hr for A5 and 43 (38-104) hr for A7 (P = 0.085). The recrudescence rates were similar between the groups. The lowest parasite count achieved during treatment (Pterm) was associated with the occurrence of recrudescence (P = 0.046, Cox regression model); it was lower for patients with a radical cure or late recrudescence than for early recrudescence (P = 0.034, t-test). Artemisinin monotherapy may offer rapid recovery and fast parasite clearance, but recrudescence is frequent. Extending the duration of monotherapy from 5 days to 7 days does not reduce recrudescence.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antimalarials,
http://linkedlifedata.com/resource/pubmed/chemical/Artemisinins,
http://linkedlifedata.com/resource/pubmed/chemical/Drugs, Chinese Herbal,
http://linkedlifedata.com/resource/pubmed/chemical/Sesquiterpenes,
http://linkedlifedata.com/resource/pubmed/chemical/artemisinine
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
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| pubmed:issn |
0002-9637
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
65
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
690-5
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:11791958-Adolescent,
pubmed-meshheading:11791958-Adult,
pubmed-meshheading:11791958-Animals,
pubmed-meshheading:11791958-Antimalarials,
pubmed-meshheading:11791958-Artemisinins,
pubmed-meshheading:11791958-Child,
pubmed-meshheading:11791958-Child, Preschool,
pubmed-meshheading:11791958-Disease-Free Survival,
pubmed-meshheading:11791958-Drug Administration Schedule,
pubmed-meshheading:11791958-Drugs, Chinese Herbal,
pubmed-meshheading:11791958-Female,
pubmed-meshheading:11791958-Humans,
pubmed-meshheading:11791958-Malaria, Falciparum,
pubmed-meshheading:11791958-Male,
pubmed-meshheading:11791958-Middle Aged,
pubmed-meshheading:11791958-Phytotherapy,
pubmed-meshheading:11791958-Plasmodium falciparum,
pubmed-meshheading:11791958-Recurrence,
pubmed-meshheading:11791958-Sesquiterpenes,
pubmed-meshheading:11791958-Treatment Outcome
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Artemisinin for treatment of uncomplicated falciparum malaria: is there a place for monotherapy?
|
| pubmed:affiliation |
Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, Amsterdam, The Netherlands.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|