|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2002-1-15
|
|
pubmed:abstractText |
The effects of propranolol and atenolol were investigated on arterial hypertension, cardiomyocyte hypertrophy, and ventricular ischaemic lesions induced by an 8-week treatment with the nitric oxide synthase inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME; 20 mg/rat per day) in Wistar rats. Propranolol and atenolol (30 mg/rat per day each) were given in the drinking water concomitantly to L-NAME. Treatment with L-NAME induced marked arterial hypertension and cardiomyocyte hypertrophy, both of which were significantly reduced by propranolol and atenolol. A marked repairing fibrosis was also observed in L-NAME-treated rats and this was significantly attenuated in animals receiving the beta-blockers. In L-NAME group, 33% mortality was observed, whereas all the animals from the other groups survived. Our study demonstrates that propranolol and atenolol reduce arterial hypertension, cardiomyocyte hypertrophy and myocardial fibrosis induced by L-NAME, suggesting that beta-blockers are of beneficial value in treatment of vascular and cardiac alterations caused by chronic nitric oxide deficiency.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0160-2446
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
39
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
201-7
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:11791005-Adrenergic beta-1 Receptor Antagonists,
pubmed-meshheading:11791005-Adrenergic beta-Antagonists,
pubmed-meshheading:11791005-Animals,
pubmed-meshheading:11791005-Atenolol,
pubmed-meshheading:11791005-Blood Pressure,
pubmed-meshheading:11791005-Body Weight,
pubmed-meshheading:11791005-Enzyme Inhibitors,
pubmed-meshheading:11791005-Fibrosis,
pubmed-meshheading:11791005-Heart,
pubmed-meshheading:11791005-Hypertension,
pubmed-meshheading:11791005-Hypertrophy, Left Ventricular,
pubmed-meshheading:11791005-Male,
pubmed-meshheading:11791005-Myocardium,
pubmed-meshheading:11791005-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:11791005-Nitric Oxide,
pubmed-meshheading:11791005-Nitric Oxide Synthase,
pubmed-meshheading:11791005-Organ Size,
pubmed-meshheading:11791005-Propranolol,
pubmed-meshheading:11791005-Rats,
pubmed-meshheading:11791005-Rats, Wistar,
pubmed-meshheading:11791005-Time Factors
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Attenuation of hypertension, cardiomyocyte hypertrophy, and myocardial fibrosis by beta-adrenoceptor blockers in rats under long-term blockade of nitric oxide synthesis.
|
|
pubmed:affiliation |
Department of Pharmacology, Faculty of Medical Sciences, Institute of Biology, UNICAMP, Campinas, São Paulo, Brazil.
|
|
pubmed:publicationType |
Journal Article
|
