Source:http://linkedlifedata.com/resource/pubmed/id/11791004
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2002-1-15
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| pubmed:abstractText |
The present experiments were designed to investigate the ability to produce nitric oxide, concentrations of N(G)-monomethyl-L-arginine (L-NMMA), and asymmetric N(G), N(G)-dimethyl-L-arginine (ADMA) in endothelial cells, endothelin-1 within the vessel wall, and the degree of intimal hyperplasia (intima/media ratio) in perimenopausal human uterine arteries. According to the tentative classification based on basal cyclic GMP levels, 16 arteries could be grouped into groups I and II consisting of eight each. Net production of the nucleotide was significantly higher in group I than that in group II. Concentration of L-NMMA plus ADMA and endothelin-1 content were significantly higher in group II. All specimens from group I were histologically normal, whereas mild to severe intimal hyperplasia was observed in group II specimens. Although considerable individual variations were detectable in the intima/media ratio, L-NMMA plus ADMA and endothelin-1 (n = 35 each), there were significant and positive correlations between three parameters, indicating that intimal hyperplasia became greater as L-NMMA plus ADMA and endothelin-1 were increased. These results suggest that endogenous nitric oxide synthase inhibitors in endothelial cells and endothelin-1 within the vessel wall are important markers of intimal hyperplasia.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arginine,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/N,N'-dimethylarginine,
http://linkedlifedata.com/resource/pubmed/chemical/N,N-dimethylarginine,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/omega-N-Methylarginine
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0160-2446
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
39
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
192-200
|
| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11791004-Adult,
pubmed-meshheading:11791004-Arginine,
pubmed-meshheading:11791004-Arteries,
pubmed-meshheading:11791004-Chromatography, High Pressure Liquid,
pubmed-meshheading:11791004-Climacteric,
pubmed-meshheading:11791004-Cyclic GMP,
pubmed-meshheading:11791004-Endothelin-1,
pubmed-meshheading:11791004-Endothelium, Vascular,
pubmed-meshheading:11791004-Enzyme Inhibitors,
pubmed-meshheading:11791004-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:11791004-Female,
pubmed-meshheading:11791004-Humans,
pubmed-meshheading:11791004-Hyperplasia,
pubmed-meshheading:11791004-Middle Aged,
pubmed-meshheading:11791004-Muscle, Smooth, Vascular,
pubmed-meshheading:11791004-Nitric Oxide,
pubmed-meshheading:11791004-Nitric Oxide Synthase,
pubmed-meshheading:11791004-Tunica Intima,
pubmed-meshheading:11791004-Tunica Media,
pubmed-meshheading:11791004-Uterus,
pubmed-meshheading:11791004-omega-N-Methylarginine
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Endogenous nitric oxide synthase inhibitors in endothelial cells, endothelin-1 within the vessel wall, and intimal hyperplasia in perimenopausal human uterine arteries.
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| pubmed:affiliation |
Comprehensive Reproductive Medicine, Regulation of Internal Environment and Reproduction, Systemic Organ Regulation, Tokyo Medical and Dental University, Japan.
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| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|