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rdf:type |
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lifeskim:mentions |
umls-concept:C0012066,
umls-concept:C0017262,
umls-concept:C0020542,
umls-concept:C0034693,
umls-concept:C0035820,
umls-concept:C0185117,
umls-concept:C0205191,
umls-concept:C0205217,
umls-concept:C0242184,
umls-concept:C0311400,
umls-concept:C0441655,
umls-concept:C0814023,
umls-concept:C1292733,
umls-concept:C1555029,
umls-concept:C1709060,
umls-concept:C2911684
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pubmed:issue |
2
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pubmed:dateCreated |
2002-1-15
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pubmed:abstractText |
Chronic hypoxic pulmonary hypertension (CH-PHT) is associated with suppressed expression and function of voltage-gated K(+) channels (Kv) in pulmonary artery (PA) smooth muscle cells (SMCs) and a shift in cellular redox balance toward a reduced state. We hypothesized that dichloroacetate (DCA), a metabolic modulator that can shift redox balance toward an oxidized state and increase Kv current in myocardial cells, would reverse CH-PHT.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Delayed Rectifier Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Dichloroacetate,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Kcnb1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Voltage-Gated,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyruvate Dehydrogenase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Shab Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/pyruvate dehydrogenase...
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
244-50
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11790708-Animals,
pubmed-meshheading:11790708-Anoxia,
pubmed-meshheading:11790708-CHO Cells,
pubmed-meshheading:11790708-Cells, Cultured,
pubmed-meshheading:11790708-Chronic Disease,
pubmed-meshheading:11790708-Cricetinae,
pubmed-meshheading:11790708-Delayed Rectifier Potassium Channels,
pubmed-meshheading:11790708-Dichloroacetate,
pubmed-meshheading:11790708-Electric Conductivity,
pubmed-meshheading:11790708-Enzyme Inhibitors,
pubmed-meshheading:11790708-Hemodynamics,
pubmed-meshheading:11790708-Hypertension, Pulmonary,
pubmed-meshheading:11790708-Immunoblotting,
pubmed-meshheading:11790708-Male,
pubmed-meshheading:11790708-Muscle, Smooth, Vascular,
pubmed-meshheading:11790708-Potassium Channels,
pubmed-meshheading:11790708-Potassium Channels, Voltage-Gated,
pubmed-meshheading:11790708-Protein Kinase Inhibitors,
pubmed-meshheading:11790708-Protein Kinases,
pubmed-meshheading:11790708-Protein-Serine-Threonine Kinases,
pubmed-meshheading:11790708-Pulmonary Artery,
pubmed-meshheading:11790708-Pyruvate Dehydrogenase Complex,
pubmed-meshheading:11790708-Rats,
pubmed-meshheading:11790708-Rats, Sprague-Dawley,
pubmed-meshheading:11790708-Shab Potassium Channels
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pubmed:year |
2002
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pubmed:articleTitle |
Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels.
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pubmed:affiliation |
Department of Medicine, University of Alberta, Edmonton, Canada. emichela@cha.ab.ca
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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