Source:http://linkedlifedata.com/resource/pubmed/id/11789730
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2002-1-14
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pubmed:abstractText |
In the thymus, the relationship between lymphofollicular hyperplasia and mucosa-associated lymphoid tissue (MALT)-type lymphoma is uncertain. We analyzed 14 cases with a diagnosis of thymic follicular hyperplasia in patients with connective tissue disease (n = 2), myasthenia gravis (n = 11), or both (n = 1). In 11 cases, well-defined reactive lymphoid follicles were surrounded by a continuous layer of medullary epithelial cells. A polyclonal rearrangement of the immunoglobulin heavy chain gene (IgH) was observed. In 3 cases, ill-defined lymphoid follicles with sheets of centrocytic-like B cells disrupting the medullary cytokeratin epithelial network were observed on certain sections. These cells expressed the phenotypic features of memory B cells with CD20, CD79a, and bcl-2 positivity and CD5, CD10, CD23, and bcl-6 negativity, and a monoclonal rearrangement of the IgH gene was detected. Appropriate sampling, cytokeratin staining, and molecular analyses may help to identify early MALT-type lymphoma developing in the setting of thymic lymphofollicular hyperplasia.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0002-9173
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
117
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
51-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11789730-Adult,
pubmed-meshheading:11789730-Antigens, CD,
pubmed-meshheading:11789730-Diagnosis, Differential,
pubmed-meshheading:11789730-Female,
pubmed-meshheading:11789730-Gene Rearrangement, B-Lymphocyte,
pubmed-meshheading:11789730-Humans,
pubmed-meshheading:11789730-Immunoglobulin Heavy Chains,
pubmed-meshheading:11789730-Lymphoma, B-Cell, Marginal Zone,
pubmed-meshheading:11789730-Male,
pubmed-meshheading:11789730-Middle Aged,
pubmed-meshheading:11789730-Mucous Membrane,
pubmed-meshheading:11789730-Thymus Gland,
pubmed-meshheading:11789730-Thymus Hyperplasia
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pubmed:year |
2002
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pubmed:articleTitle |
Mucosa-associated lymphoid tissue of the thymus hyperplasia vs lymphoma.
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pubmed:affiliation |
Department of Pathology and Molecular Biology, University of Bordeaux 2, Pessac, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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