Source:http://linkedlifedata.com/resource/pubmed/id/11788473
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2002-1-14
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| pubmed:abstractText |
Increased levels of physical activity may improve the lipid profile, but is this effect identical across apolipoprotein E (apoE) genotypes? A population-based cross-sectional survey conducted from 1999 to 2000 included 1708 randomly selected men and women aged 35 to 74 years. A validated physical activity questionnaire measured, for each participant, the total energy expenditure and its percentage used in high-intensity activities (%high-intensity activity), eg, brisk walking and sports. The effects of the apoEx%high-intensity activity interaction on the lipid profile were investigated by using multiple linear regression models. Among men, increased %high-intensity activity had greater protective effects in the apoE4 group regarding (1) high density lipoprotein (HDL) cholesterol (P<0.001), compared with either the apoE2 (interaction P=0.05) or apoE3 (interaction P<0.03) groups, and (2) triglycerides (P<0.03), compared with the apoE3 group (interaction P=0.07). A 10% increase of %high-intensity activity by an apoE4 man would correspond with a 0.07-mmol/L increase in HDL cholesterol and a -0.15-mmol/L decrease in triglycerides. Among women, only the protective effects of physical activity on HDL cholesterol in the apoE4 group versus the apoE2 group was statistically significant. Spending a larger fraction of the total energy expenditure in high-intensity activities may counteract the atherogenic effects of the epsilon4 allele on the lipid profile.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1524-4636
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
22
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
133-40
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11788473-Activities of Daily Living,
pubmed-meshheading:11788473-Adult,
pubmed-meshheading:11788473-Aged,
pubmed-meshheading:11788473-Algorithms,
pubmed-meshheading:11788473-Apolipoproteins E,
pubmed-meshheading:11788473-Cholesterol, HDL,
pubmed-meshheading:11788473-Cholesterol, LDL,
pubmed-meshheading:11788473-Cross-Sectional Studies,
pubmed-meshheading:11788473-Energy Metabolism,
pubmed-meshheading:11788473-Exercise,
pubmed-meshheading:11788473-Female,
pubmed-meshheading:11788473-Genotype,
pubmed-meshheading:11788473-Humans,
pubmed-meshheading:11788473-Male,
pubmed-meshheading:11788473-Middle Aged,
pubmed-meshheading:11788473-Regression Analysis,
pubmed-meshheading:11788473-Sex Characteristics,
pubmed-meshheading:11788473-Switzerland,
pubmed-meshheading:11788473-Triglycerides
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| pubmed:year |
2002
|
| pubmed:articleTitle |
Physical activity may modulate effects of ApoE genotype on lipid profile.
|
| pubmed:affiliation |
Division d'Epidémiologie Clinique Hôpitaux Universitaires de Genève, Centre Médical Universitaire, Geneva, Switzerland. martine.bernstein@hcuge.ch
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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