| pubmed-article:11788337 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11788337 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:11788337 | lifeskim:mentions | umls-concept:C0033551 | lld:lifeskim |
| pubmed-article:11788337 | lifeskim:mentions | umls-concept:C0332685 | lld:lifeskim |
| pubmed-article:11788337 | lifeskim:mentions | umls-concept:C1819439 | lld:lifeskim |
| pubmed-article:11788337 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:11788337 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11788337 | pubmed:dateCreated | 2002-1-14 | lld:pubmed |
| pubmed-article:11788337 | pubmed:abstractText | Macrophage (Mphi) prostaglandin (PG)E(2) production has been implicated in immunosuppression and increased susceptibility to sepsis after thermal injury. Deficient interleukin (IL)-12 production has also been implicated in these postburn complications. The present study examined the relationship between Mphi cyclooxygenase (COX)-2 activity and IL-12 production after thermal injury. C57BL/6 female mice were subjected to a 25% total body surface area full-thickness burn. Mphi were isolated 7 days later, or the mice were subjected to sepsis by cecal ligation and puncture (CLP). IL-12 production by Mphi from injured mice was suppressed by >50%, whereas COX-2 expression and PGE(2) production were increased twofold. The COX-2 inhibitor NS-398 suppressed PGE(2) production and normalized IL-12 production in the injury group, whereas it had no effect on IL-10 production. Injured mice subjected to CLP had lower IL-12 plasma levels compared with sham-treated mice subjected to CLP. NS-398 treatment prevented the suppression in plasma IL-12 levels in the injury group. Thus elevated Mphi COX-2 activity, independent of IL-10, suppresses Mphi IL-12 production after thermal injury and may play an important role in the observed immunosuppression under such conditions. | lld:pubmed |
| pubmed-article:11788337 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11788337 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11788337 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11788337 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11788337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11788337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11788337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11788337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11788337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11788337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11788337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11788337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11788337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11788337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11788337 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11788337 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11788337 | pubmed:issn | 0363-6143 | lld:pubmed |
| pubmed-article:11788337 | pubmed:author | pubmed-author:SchwachaMarti... | lld:pubmed |
| pubmed-article:11788337 | pubmed:author | pubmed-author:AyalaAlfredA | lld:pubmed |
| pubmed-article:11788337 | pubmed:author | pubmed-author:BlandKirby... | lld:pubmed |
| pubmed-article:11788337 | pubmed:author | pubmed-author:ChaudryIrshad... | lld:pubmed |
| pubmed-article:11788337 | pubmed:author | pubmed-author:ChungChun-Shi... | lld:pubmed |
| pubmed-article:11788337 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11788337 | pubmed:volume | 282 | lld:pubmed |
| pubmed-article:11788337 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11788337 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11788337 | pubmed:pagination | C263-70 | lld:pubmed |
| pubmed-article:11788337 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:11788337 | pubmed:meshHeading | pubmed-meshheading:11788337... | lld:pubmed |
| pubmed-article:11788337 | pubmed:meshHeading | pubmed-meshheading:11788337... | lld:pubmed |
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| pubmed-article:11788337 | pubmed:meshHeading | pubmed-meshheading:11788337... | lld:pubmed |
| pubmed-article:11788337 | pubmed:meshHeading | pubmed-meshheading:11788337... | lld:pubmed |
| pubmed-article:11788337 | pubmed:meshHeading | pubmed-meshheading:11788337... | lld:pubmed |
| pubmed-article:11788337 | pubmed:meshHeading | pubmed-meshheading:11788337... | lld:pubmed |
| pubmed-article:11788337 | pubmed:meshHeading | pubmed-meshheading:11788337... | lld:pubmed |
| pubmed-article:11788337 | pubmed:meshHeading | pubmed-meshheading:11788337... | lld:pubmed |
| pubmed-article:11788337 | pubmed:meshHeading | pubmed-meshheading:11788337... | lld:pubmed |
| pubmed-article:11788337 | pubmed:meshHeading | pubmed-meshheading:11788337... | lld:pubmed |
| pubmed-article:11788337 | pubmed:meshHeading | pubmed-meshheading:11788337... | lld:pubmed |
| pubmed-article:11788337 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11788337 | pubmed:articleTitle | Cyclooxygenase 2-mediated suppression of macrophage interleukin-12 production after thermal injury. | lld:pubmed |
| pubmed-article:11788337 | pubmed:affiliation | Center for Surgical Research, Department of Surgery, University of Alabama at Birmingham, 35294, USA. Martin.Schwacha@ccc.uab.edu | lld:pubmed |
| pubmed-article:11788337 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11788337 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11788337 | lld:pubmed |
