Linked Life Data

11787954

Source:http://linkedlifedata.com/resource/pubmed/id/11787954

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-1-11
pubmed:abstractText
The DNA binding properties of three novel extended aromatic bisamidines (1-3) possessing different dicationic terminal side chains were studied. Data from the ethidium displacement assay showed that bisamidines 1-3 have significant affinity for DNA. We studied the cytotoxic activity of bisamidines 1-3 and Hoechst 33258 in the cultured breast cancer MCF-7 cells. These data show that in broad terms the cytotoxic potency of bisamidines 1-3 in the cultured breast cancer MCF-7 cells decreases with the size of the alkyl group substituent (cyclopropyl > isopropyl > cyclopentyl), in accord with their increases in DNA affinity, as shown by the binding constant values. The bisamidines 1-3 showed comparable antitumor activity to Hoechst 33258.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1230-6002
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
143-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:articleTitle
DNA-binding properties and cytotoxicity of extended aromatic bisamidines in breast cancer MCF-7 cells.
pubmed:affiliation
Department of Medicinal Chemistry and Drug Technology, Medical Academy of Bia?ystok, Poland. kbiel@amb.ac.bialystok.pl
pubmed:publicationType
Journal Article, Comparative Study