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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-1-11
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pubmed:abstractText |
In the lungs of cystic fibrosis patients, overproduction of mucus leads to morbidity and mortality by obstructing airflow and shielding bacteria from antibiotics. Here we demonstrate that overproduction of mucus is a direct result of the activation of mucin gene expression by Gram-positive bacteria. Bacterial lipoteichoic acid activates the platelet-activating factor receptor, which is G protein-coupled. This results in activation of a disintegrin and metalloproteinase (ADAM10), kuzbanian, cleavage of pro heparin-binding epidermal growth factor and activation of the epidermal growth factor receptor. Unlike responses in macrophages, the epithelial-cell response to lipoteichoic acid does not require Toll-like receptor 2 or 4.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid Precursor Protein Secretases,
http://linkedlifedata.com/resource/pubmed/chemical/Aspartic Acid Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/BACE1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Disintegrins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/MUC2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Metalloendopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Mucin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Mucins,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/TLR2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Teichoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/kuzbanian protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/lipoteichoic acid,
http://linkedlifedata.com/resource/pubmed/chemical/platelet activating factor receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1078-8956
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
41-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11786905-Amyloid Precursor Protein Secretases,
pubmed-meshheading:11786905-Aspartic Acid Endopeptidases,
pubmed-meshheading:11786905-Disintegrins,
pubmed-meshheading:11786905-Drosophila Proteins,
pubmed-meshheading:11786905-Endopeptidases,
pubmed-meshheading:11786905-Epithelial Cells,
pubmed-meshheading:11786905-Gram-Positive Bacteria,
pubmed-meshheading:11786905-Humans,
pubmed-meshheading:11786905-Lipopolysaccharides,
pubmed-meshheading:11786905-Lung,
pubmed-meshheading:11786905-Membrane Glycoproteins,
pubmed-meshheading:11786905-Metalloendopeptidases,
pubmed-meshheading:11786905-Models, Genetic,
pubmed-meshheading:11786905-Mucin-2,
pubmed-meshheading:11786905-Mucins,
pubmed-meshheading:11786905-Mucus,
pubmed-meshheading:11786905-Platelet Membrane Glycoproteins,
pubmed-meshheading:11786905-Receptor, Epidermal Growth Factor,
pubmed-meshheading:11786905-Receptors, Cell Surface,
pubmed-meshheading:11786905-Receptors, G-Protein-Coupled,
pubmed-meshheading:11786905-Signal Transduction,
pubmed-meshheading:11786905-Staphylococcal Infections,
pubmed-meshheading:11786905-Staphylococcus aureus,
pubmed-meshheading:11786905-Teichoic Acids,
pubmed-meshheading:11786905-Toll-Like Receptor 2,
pubmed-meshheading:11786905-Toll-Like Receptors,
pubmed-meshheading:11786905-Transcriptional Activation
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pubmed:year |
2002
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pubmed:articleTitle |
Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells.
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pubmed:affiliation |
Biomedical Sciences Program, Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco, California, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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